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All Journal Jurnal Kedokteran Diponegoro Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Chrisantus Ronald Bria Seran
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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PENGARUH PAPARAN ASAPMESIN DIESEL TERHADAP GAMBARAN HISTOLOGI PARU PADA PENDERITA ALERGI (STUDY EXPERIMENTAL PADA MENCIT BALB/C) Chrisantus Ronald Bria Seran; Suprihati Suprihati; Yanuar Iman Santoso
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 2 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.326 KB) | DOI: 10.14710/dmj.v7i2.20672

Abstract

Latar Belakang : Alergi merupakan hasil dari interaksi antara faktor predisposisi genetik atopi dengan alergen lingkungan, infeksi dan polutan. Rinitis alergi adalah suatu gangguan pernapasan pada hidung yang disebabkan oleh reaksi peradangan mukosa yang diperantarai oleh imunoglobulin E (IgE) setelah terjadi paparan alergen. Partikel hasil pembakaran mesin diesel menyebabkan peningkatan IgE dengan berbagai mekanisme dan inflamasi lokal pada saluran pernafasan, sehingga terjadi peningkatan kontak antara jaringan dengan alergen sehingga timbul respon imun. Maka dapat diketahui pengaruh paparan asap mesin diesel terhadap struktur histopatologi paru mencit yang terpapar asap mesin diesel dengan jumlah eosinofil pada paru mencit tersebut.Tujuan : Mengetahui paparan asap mesin diesel yang mempengaruhi kerusakan epitel jaringan paru pada penyakit alergi.Metode : Sampel sebanyak 15 mencit dipilih secara simple random sampling. mencit dibagi menjadi tiga kelompok. Kelompok Kontrol Negatif(K) diberikan pakan standar dan air minum selama masa penelitian  Kelompok Kontrol Positif (K1) diinjeksi OVA secara intraperitoneal. Selanjutnya diberikan OVA 1% intranasal. Kelompok Perlakuan 1 (P1) diberikan paparan asap mesin diesel setelah diinduksi OVA.Hasil : Rata-rata jumlah eosinophil kelompok kontrol (-) 0,52, kontrol (+) 2,12 dan perlakuan 2,36. Perbandingan antara kelompok kontrol (-) dengan kelompok kontrol (+) dan perbandingan antara kelompok kontrol (-) dengan kelompok perlakuan diperoleh nilai p sebesar 0.008. perbandingan antara kelompok kontrol (+) dengan kelompok perlakuan diperoleh nilai p sebesar 0.246Kesimpulan : Jumlah eosinofil di jaringan peribronkhial paru pada kelompok control positif yang diinduksi ovalbumin lebih tinggi dibandingkan dengan kelompok control negatif yang tidak diinduksi ovalbumin.
Mangosteen Nanoextract and Bone Regeneration in Diabetes: A Meta-Analysis of ALP and Osteocalcin Modulation during Fracture Callus Formation Chrisantus Ronald Bria Seran; Yuriz Bakthiar; MI Widiastuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1261

Abstract

Background: Diabetic fracture healing is often impaired, leading to prolonged recovery and increased risk of non-union. Garcinia mangostana L. (mangosteen) possesses anti-inflammatory, antioxidant, and potentially osteogenic properties. This meta-analysis investigates the effect of mangosteen nanoextract on bone regeneration in diabetic fracture models, focusing on the modulation of alkaline phosphatase (ALP) and osteocalcin (OCN) levels during callus formation. Methods: A systematic literature search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases, covering publications from January 2013 to May 2024. Studies evaluating the effects of mangosteen nanoextract on ALP and OCN levels in in vivo diabetic fracture models were included. Data on ALP and OCN levels at various time points during callus formation were extracted. A random-effects model was used to calculate the standardized mean difference (SMD) and 95% confidence intervals (CIs) for ALP and OCN levels between mangosteen nanoextract-treated and control groups. Heterogeneity was assessed using the I² statistic. Results: Five studies met the inclusion criteria, encompassing a total of 150 diabetic animal models (rats or mice) with induced fractures. Mangosteen nanoextract treatment was associated with a significant increase in ALP levels during the early phase of callus formation (SMD = 1.25; 95% CI: 0.80, 1.70; p < 0.001; I² = 65%). Similarly, OCN levels were significantly higher in the nanoextract-treated group during the later stages of callus formation (SMD = 0.98; 95% CI: 0.55, 1.41; p < 0.001; I² = 58%). Conclusion: This meta-analysis suggests that mangosteen nanoextract may enhance bone regeneration in diabetic fracture models by modulating ALP and OCN levels, key biomarkers of osteoblast activity and bone formation. Further research, including well-designed clinical trials, is warranted to confirm these findings and translate them into clinical practice.
Mangosteen Nanoextract and Bone Regeneration in Diabetes: A Meta-Analysis of ALP and Osteocalcin Modulation during Fracture Callus Formation Chrisantus Ronald Bria Seran; Yuriz Bakthiar; MI Widiastuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1261

Abstract

Background: Diabetic fracture healing is often impaired, leading to prolonged recovery and increased risk of non-union. Garcinia mangostana L. (mangosteen) possesses anti-inflammatory, antioxidant, and potentially osteogenic properties. This meta-analysis investigates the effect of mangosteen nanoextract on bone regeneration in diabetic fracture models, focusing on the modulation of alkaline phosphatase (ALP) and osteocalcin (OCN) levels during callus formation. Methods: A systematic literature search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases, covering publications from January 2013 to May 2024. Studies evaluating the effects of mangosteen nanoextract on ALP and OCN levels in in vivo diabetic fracture models were included. Data on ALP and OCN levels at various time points during callus formation were extracted. A random-effects model was used to calculate the standardized mean difference (SMD) and 95% confidence intervals (CIs) for ALP and OCN levels between mangosteen nanoextract-treated and control groups. Heterogeneity was assessed using the I² statistic. Results: Five studies met the inclusion criteria, encompassing a total of 150 diabetic animal models (rats or mice) with induced fractures. Mangosteen nanoextract treatment was associated with a significant increase in ALP levels during the early phase of callus formation (SMD = 1.25; 95% CI: 0.80, 1.70; p < 0.001; I² = 65%). Similarly, OCN levels were significantly higher in the nanoextract-treated group during the later stages of callus formation (SMD = 0.98; 95% CI: 0.55, 1.41; p < 0.001; I² = 58%). Conclusion: This meta-analysis suggests that mangosteen nanoextract may enhance bone regeneration in diabetic fracture models by modulating ALP and OCN levels, key biomarkers of osteoblast activity and bone formation. Further research, including well-designed clinical trials, is warranted to confirm these findings and translate them into clinical practice.
Co-Authors MI Widiastuti Suprihati Suprihati Yanuar Iman Santoso Yuriz Bakthiar