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All Journal Jurnal Kedokteran Diponegoro Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Mada Aji Prakoso
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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ANALISA GAMBARAN POST MORTEM MAKROSKOPIS DAN MIKROSKOPIS ORGAN PARU DAN USUS HALUS PADA TIKUS WISTAR SETELAH PEMBERIAN WARFARIN LD-50 DAN LD-100 Mada Aji Prakoso; Gatot Suharto; Siti Amarwati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 2 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.535 KB) | DOI: 10.14710/dmj.v5i2.11571

Abstract

Introduction : More than 800.000 people died every years from suicide, and in 2012 suicidal acts on 15-29 years old become the second most cause. Suicide by poison is one of the most used, Warfarins role here aside from its therapeutical effect as anticoagulant, and also as rodenticide in household often misused for a way to suicide. This study is aimed to analyze the differences of macroscopic and microscopics representation in lungs and small intestine on Wistar mouse after LD50 dan LD100 Warfarin administration.Method : This is experimental analytic study, using total sample of 27 mouse, male Rattus norvegicus as the sample. These 27 mouse will be divided into 3 group, 9 eachs. First group is administered LD50 Warfarin, second group is administered LD100 Warfarin, and the third group as control.Result : there is no differences in macroscopic aspect of lung control group with group LD50 dan LD100, in microscopic showed massive haemmorhage. On small intestines there is differences from control group with LD50 dan LD100.Conclussion : Toxic effect from warfarin showed in microscopic view of organs with hemorrhage and destruction of its tissues.
Delayed Right-Sided Traumatic Diaphragmatic Rupture Complicated by Hepatothorax and Visceral Herniation a Decade Post-Trauma: A Case Report Mada Aji Prakoso; Albertus Ari Adrianto; Parish Budiono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1586

Abstract

Background: Traumatic diaphragmatic rupture (TDR) is a rare consequence of high-energy blunt trauma, accounting for less than 1% of all traumatic injuries. Right-sided ruptures are particularly uncommon, representing only 5% to 20% of cases, largely due to the protective anatomical positioning of the liver. Consequently, right-sided injuries are notoriously difficult to detect, often leading to a delayed diagnosis. Case presentation: We present the case of a 29-year-old female who presented with progressive dyspnea ten years after sustaining a motor vehicle collision. Her initial injury was managed as a right-sided hemothorax, with the diaphragmatic defect remaining undetected. A decade later, imaging revealed an elevated right hemidiaphragm with massive herniation of the liver, gallbladder, transverse colon, and omentum into the right thoracic cavity. The patient underwent a successful abdomino-thoracotomy with primary repair of a 10 cm x 4 cm defect, reinforced with a prosthetic mesh. She was discharged on postoperative day seven with an uneventful recovery. Conclusion: This case emphatically highlights the persistent, lifelong risk of delayed visceral herniation following thoracoabdominal trauma. A high index of suspicion must be maintained for patients presenting with delayed respiratory symptoms, as prompt surgical intervention yields excellent outcomes.
Delayed Right-Sided Traumatic Diaphragmatic Rupture Complicated by Hepatothorax and Visceral Herniation a Decade Post-Trauma: A Case Report Mada Aji Prakoso; Albertus Ari Adrianto; Parish Budiono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1586

Abstract

Background: Traumatic diaphragmatic rupture (TDR) is a rare consequence of high-energy blunt trauma, accounting for less than 1% of all traumatic injuries. Right-sided ruptures are particularly uncommon, representing only 5% to 20% of cases, largely due to the protective anatomical positioning of the liver. Consequently, right-sided injuries are notoriously difficult to detect, often leading to a delayed diagnosis. Case presentation: We present the case of a 29-year-old female who presented with progressive dyspnea ten years after sustaining a motor vehicle collision. Her initial injury was managed as a right-sided hemothorax, with the diaphragmatic defect remaining undetected. A decade later, imaging revealed an elevated right hemidiaphragm with massive herniation of the liver, gallbladder, transverse colon, and omentum into the right thoracic cavity. The patient underwent a successful abdomino-thoracotomy with primary repair of a 10 cm x 4 cm defect, reinforced with a prosthetic mesh. She was discharged on postoperative day seven with an uneventful recovery. Conclusion: This case emphatically highlights the persistent, lifelong risk of delayed visceral herniation following thoracoabdominal trauma. A high index of suspicion must be maintained for patients presenting with delayed respiratory symptoms, as prompt surgical intervention yields excellent outcomes.
Co-Authors Albertus Ari Adrianto Aminuyati Gatot Suharto Parish Budiono