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All Journal Microbiology Indonesia Riset Informasi Kesehatan
VIVI SETIAWATY
National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Five Unique Amino Acid Residues of Hemagglutinin (HA) Proteins of Swine Influenza A (H1N1) Detected in 2009 in Jakarta, Indonesia ANDI YASMON; YULIANTY MUHAYAR; VIVI SETIAWATY; BETI ERNAWATI DEWI; BUDIMAN BELA; FERA IBRAHIM
Microbiology Indonesia Vol. 6 No. 2 (2012): June 2012
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (669.535 KB) | DOI: 10.5454/mi.6.2.3

Abstract

Nine HA genes of influenza A (H1N1) viruses originating from swine which were detected in 2009 in Jakarta, Indonesia, were characterized in this study. Nasopharyngeal and/or pharyngeal samples were extracted to obtain viral RNA genomes. Amplification of the HA segment was performed by using the reverse transcription-polymerase chain reaction (RT-PCR), and followed by nested PCR in cases of RT-PCR negative. DNA sequencing was performed by using eight overlapping primers. All the Jakarta strains were closely related to vaccine strain A/California/07/2009. Nine amino acid changes were found in the Jakarta strains, and 5 (P100S, S220T, G239D, R240Q, and I338V) of those were unique to all Jakarta strains with respect to strain A/California/07/2009 used to produce vaccine. An I338V substitution was detected in a cleavage site of HA and no amino acid changes were detected in potential sites for N-linked glycosylation. For seven sites (positions 131, 158, 160, 183, 187, 222, and 227) playing an important role in viral attachment to host receptor, none of the expected amino acid changes was detected; however, a S220T substitution close to amino acid 222 was found in all the Jakarta strains. All amino acid changes potentially affect the pathogenicity of the viruses and the efficacy of strain A/California/07/2009 in neutralizing the Jakarta strains.
Influenza related pneumonia in children under five years old in Indonesia : An analysis of the risk factors Ira Wignjadiputro; Ni Ketut Susilarini; Vivi Setiawaty; Renti Mahkota
Riset Informasi Kesehatan Vol 7 No 2 (2018): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.036 KB) | DOI: 10.30644/rik.v7i2.119

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Abstract Background: Pneumonia is more commonly among children under five years old and caused by several risk factors. Pneumonia causes 1.9 – 2.2 million children death worldwide every year, in which 1.3 million (81%) generally occurs in first 2 years of life. Seventy two percent of pneumonia occurs in children under five years old in 15 countries. Indonesia was the 7th highest in the world. The prevalence of pneumonia in Indonesia was 18.5/1000 population and only 1.6/1000 received treatment. This study aim to elaborate the risk factors of the influenza related pneumonia in children under five years old. Method: The pneumonia control program in Ministry of Health focuses on early detection and treatment for bacterial pneumonia in community. Severe acute respiratory infection (SARI) can develop fatal pneumonia. We collected data from the pneumonia surveillance database in the Acute Respiratory Infection subdirectorate. Results: Influenza related pneumonia was 13% of acute lower respiratory infection in pediatric. The number of children under five years old death estimation was 28,000-115,000 and 99% happened in developing countries. The aim of this review is to understand influenza related pneumonia in Indonesia and global. Summary: In Indonesia, proportion of influenza from SARI surveillance was 12% and mainly in children under five years old (36%). Pneumonia was 18% of SARI cases with positive influenza. The effect of Influenza become pneumonia remain unclear.
Co-Authors Andi Yasmon Beti Ernawati Dewi Budiman Bela Fera Ibrahim Ira Wignjadiputro Ni Ketut Susilarini Renti Mahkota YULIANTY MUHAYAR