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Abykhair Muhammad
Laboratory of Pharmaceutical Biotechnology, Research Group Pharmaceutics, School of Pharmacy, Bandung Institute of Technology, Ganesa No. 10, Bandung 40132, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Relationship and structural diversity of bacterial manganese superoxide dismutases and the strategy for its application in therapy and cosmetics Debbie S. Retnoningrum; Aluicia Anita Artarini; Wangsa T. Ismaya; Abykhair Muhammad; Muhammad D. Fadilah; Ratna A. Utami
Microbiology Indonesia Vol. 15 No. 4 (2021): December
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2349.93 KB) | DOI: 10.5454/mi.15.4.2

Abstract

Manganese superoxide dismutase (MnSOD) from bacteria shares high amino acid sequence homology and nearly identical structure. Despite of that, their characteristics are diverse, which likely due to their bacterial origin and adaptation to the environment. Most importantly, their structural similarity extends to eukaryotic MnSOD, i.e. human. Therefore, structural study of bacterial MnSOD is relevant to its human SOD and henceforth for its use in human as a therapeutic agent or a cosmetic ingredient. Further, eukaryotic MnSOD occurs as a tetramer while almost all of the prokaryotic are dimeric. In this review, relationship between the amino acid sequences and structures of MnSOD as well as their origin and evolution is discussed. The structures of FeSOD and cambialistic SOD, which are MnSOD closest homologs, are visited as the comparison. This study provides an insight to potential safe application of bacterial MnSOD, including necessary modifications to obtain desired characteristics for applications in human.
Co-Authors Aluicia Anita Artarini Debbie S. Retnoningrum Muhammad D. Fadilah Ratna A. Utami Wangsa T. Ismaya