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All Journal Jurnal Kedokteran Brawijaya Jurnal Ilmiah Kesehatan Sandi Husada
Indah Dina Maritha
Program Studi Pendidikan Dokter Fakultas Kedokteran Unversitas Brawijaya Malang
Health Professions Medicine & Pharmacology Nursing Public Health

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EKSPRESI CYTOSOLIC ASPARTATE-SPECIFIC CYSTEINE PROTEASE-3 (CASPASE-3) PADA JARINGAN HATI RATTUS NORVEGICUS (WISTAR) SETELAH PEMBERIAN SUBKRONIK AFLATOKSIN B1 (AFB1) Maritha, Indah Dina; Supranowo, Supranowo; Lyrawati, Diana
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1838.995 KB) | DOI: 10.21776/ub.jkb.2006.022.03.4

Abstract

Aflatoksin B1(AFB1) is one of the toxic agents produced by Aspergillus flavus that frequently contaminates foods not properly stored. AFB1 undergoes biotransformation which may result in the production of reactive oxygenspecies (ROS) hazardous to liver cells. Following a cascade of oxidative reaction, ROS will cause the mitochondria torelease cytochrome c which subsequently activates caspase-3, leading to apoptosis. In this present study we evaluated the effect of aflatoxin B1 on the expression of caspase-3 in the liver. AFB1 was administered per oral, at different dosage and length of exposure, subchronically. This study was carried out as a factorial designed experiment with  two factors. The first was dosage factor i.e 0, 10, 15 and 20 µg (0; 0,05; 0,075; 0,1 µg/g BW) and the second was exposure time factor i.e. 12, 16 and 20 weeks. Rattus norvegicus strain Wistar aged approximately eight weeks old and weighed 180-200 g were used as the experimental animals. The expression of  caspase-3 was examined by using immunohistochemistry. The results showed that the expression of caspase-3 increased significantly (p = 0,000) with the escalation of AFB1 in dosage and/or exposure time (p = 0,001). In the interaction between dose and exposure time of AFB1an increase in the expression of caspase-3 was also observed (p = 0,000). Interestingly, these studies also revealed thatin the liver tissues there was a limitation in the expression of caspase-3, where the raising of further AFB1 dosage and length of exposure were not followed by further increase of the caspase-3.
Surgical management of non-obstetric vulvar hematoma in a pediatric patient: A Case Report Singh, Karnel; Maritha, Indah Dina
Jurnal Ilmiah Kesehatan Sandi Husada Vol 14 No 2 (2025): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v14i2.1281

Abstract

Introduction: Vulvar hematoma is an uncommon condition in pediatric patients, often caused by blunt trauma to the perineum. Its management differs from that in adults due to the anatomical and physiological characteristics of children. Proper diagnosis and treatment are essential to prevent complications such as necrosis, infection, or recurrent bleeding. Methods: An 11-year-old girl presented with pain and swelling in the genital region following a fall in a sitting position with a mobile phone underneath her. Physical examination revealed a right-sided vulvar hematoma measuring 7×7×5 cm. Due to the progressive enlargement and pain, surgical evacuation was performed under anesthesia, followed by drainage and wound suturing with vicryl 2.0 thread. Postoperative management included pediatric co-treatment, analgesics, and antibiotics. Results: The patient showed significant improvement within three days post-surgery, with reduction in swelling and pain. The drain was removed on the second postoperative day, and wound healing progressed well without complications. The case emphasizes the importance of prompt intervention to prevent pressure necrosis and infection, especially in large hematomas or those with progressive symptoms. Conclusion: Non-obstetric vulvar hematoma, although rare in children, requires prompt evaluation and management. Surgical evacuation is recommended for large or progressively enlarging hematomas to prevent necrosis and other complications. Appropriate surgical technique, postoperative care, and interprofessional collaboration ensure optimal patient outcomes
Co-Authors Diana Lyrawati Singh, Karnel Supranowo Supranowo