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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Parapemikir Jurnal Ilmiah Farmasi
Yithro Serang
Akademi Farmasi Nusaputera Semarang
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics

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Uji Akivitas Imunomodulator Ekstrak Buah Petai (Parkia speciosa Hassk.) terhadap Titer Imunoglobulin (IgG) pada Mencit Balb/c yang Diinduksi dengan SDMD Yithro Serang; Ferika Indrasari
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i1.1306

Abstract

Immunomodulators are substances or drugs that can modulate the function and activity of the immune system. Most of the medicinal plants that have been studied prove the presence of immunostimulators, while immunosuppressors are still rare. Petai plants can function as antioxidants. There is a close relationship between antioxidants and the immune system giving antioxidants can stimulate and protect the cellular immune system. The purpose of this study was to determine the effect of administration and effective dose of petai fruit (Parkia speciosa Hassk) ethanol extract on increasing IgG titer in Balb / c mice induced by SDMD.This research method was started with Petai extraction and then tested for chemical content. Experimental animals consisted of 25 mice divided into 5 treatment groups, each group consisting of 5 mice. All groups were immunized with 1% SDMD as much as 0.2 ml / 20 g BB on day 8 (after being acclimatized for 7 days) intravenously. Test preparation is given orally for 7 days. On day 14, blood collection from retro orbital plexus was performed to collect serum and examined immunoglobulin G titers with indirect ELISA method.The benefit to be obtained from this study is to prove the ethanol extract of petai fruit (Parkia speciosa Hassk) can increase the immune system against foreign compounds with an increase in IgG titer in Balb / c mice induced by HRD. The results of Petai Fruit Extract Dosage 4.125 mg / KgBB, 8.25 mg / Kg BB and a dose of 16.5 mg / Kg BB give an effect on increasing IgG titers. The dose of 16.5 mg is better than stimouno in increasing IgG levels of mice induced by HRD.Keywords— Petai (Parkia speciosa Hassk), IgG, SDMD,ELISA
KAJIAN EFEKTIVITAS FILTRAT PERASAN, MINYAK ATSIRI DAN EKSTRAK ETANOL DAUN KETUMBAR (Coriandrum sativum L.) Felisia Bani; Yithro Serang; Safitri
Jurnal Farmasi & Sains Indonesia Vol 1 No 1 (2018)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Indonesia merupakan salah satu negara yang memiliki beraneka ragam tumbuhan yang tersebar di seluruh wilayahnya. Banyak usaha yang dilakukan untuk mengisolasi senyawa baru terhadap berbagai macam tumbuhan yang belum banyak di teliti sehingga diharapkan dapat lebih banyak menemukan senyawa baru. Salah satu tanaman yang diharapkan banyak mengandung senyawa baru adalah daun ketumbar (Coriandrum sativum L.). Penelitian ini bertujuan untuk mengkaji senyawa kimia yang berpotensial sebagai bahan obat yang terkandung dalam Coriandrum sativum L., evektivitas filtrat perasan Coriandrum sativum L., minyak atsiri Coriandrum sativum L. dan ekstrak etanol Coriandrum sativum L. sebagai antibakteri dalam berbagai seri konsentrasi serta menguji aktivitas antioksidan dengan menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazil). Hasil yang diperoleh menunjukkan ekstrak etanol daun ketumbar pada konsentrasi 100 ppm dapat menghambat pertumbuhan bakteri Staphylococcus aureus sebesar 26,0 mm dan bakteri Salmonella typhi sebesar 27,7 mm. Sedangkan uji aktivitas antioksidan daun ketumbar menunjukkan hasil filtrat perasan daun ketumbar, minyak atsiri daun ketumbar dan ekstrak etanol daun ketumbar memiliki aktivitas sebagai antioksidan dengan nilai IC50 berturut-turut sebesar 113,57 µg/mL, 131,43 µg/mL dan 92,34 µg/mL. Hasil uji kromatografi lapis tipis menunjukkan adanya kandungan flavonoid, alkaloid, saponin dan tanin pada daun ketumbar.
Co-Authors Felisia Bani Ferika Indrasari Ferika Indrasari Safitri