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All Journal Majalah Kedokteran Bandung Althea Medical Journal
Abdul Hadi Martakusumah
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
Medicine & Pharmacology

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Level of Knowledge about Hypertension in Cilayung Village District Jatinangor, Sumedang Qisthi, Dian; Wiwaha, Guswan; Martakusumah, Abdul Hadi; Setiawati, Elsa Pudji
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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  Background: Hypertension known as a silent killer because it is often asymptomatic and causes target organ damage. Prevention of hypertension and its complications are pharmacological and non-pharmacological therapy, making holistic knowledge of hypertension is paramount to establish good behavior. This is needed by hypertensive and non-hypertensive individuals. Therefore, the study was conducted to identify any knowledge level differences between hypertensive and non-hypertensive groups. Methods: Respondents were 116 Cilayung residents equally divided in hypertensive and non-hypertensive groups. Respondent’s blood pressure was measured and they completed questionnaires during October 2012. This is an observational analytic cross-sectional study with chi-square test.Results: The respondents’ characteristics in both groups dominated by females, aged 50-59 years, housewives, with elementary school background. Most respondents in both groups had sufficient knowledge about hypertension in general, but for knowledge about risk factors, treatment, and complications were still not enough. The result of the chi-square test was not significant with P=0.676. It was due to distributed health promotion and non-matched respondents’age.Conclusion: There is no difference in level of knowledge about hypertension between both groups in Cilayung.Keywords: Differences, hypertension, level of knowledge DOI: 10.15850/amj.v2n1.449 
Hubungan antara QT Variability Index dan Laju Filtrasi Glomerulus pada Penyakit Ginjal Kronik Predialisis Sugiantoro, -; Purnomowati, Augustine; Martakusumah, Abdul Hadi; Achmad, Chaerul
Majalah Kedokteran Bandung Vol 44, No 4 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Penderita penyakit ginjal kronik (PGK) mempunyai risiko yang tinggi untuk mengalami aritmia ventrikel dan kematian mendadak (sudden cardiac death/SCD). Angka kejadian SCD pada penderita PGK meningkat seiring dengan menurunnya laju filtrasi glomerulus (glomerular filtration rate/GFR). Mekanisme patofisiologi yang mendasari SCD pada umumnya aritmia ventrikel yang berhubungan dengan ketidakstabilan repolarisasi miokardium. QT variability index (QTVI), suatu indeks yang menggambarkan ketidakstabilan repolarisasi miokardium, merupakan prediktor yang kuat untuk terjadi aritmia fatal dan SCD. Penelitian ini merupakan studi observasi potong lintang untuk menilai hubungan antara QTVI dan GFR pada penderita PGK predialisis dengan GFR <60 mL/menit. Penelitian ini dilakukan pada penderita PGK yang berobat ke Poliklinik Ginjal Hipertensi Rumah Sakit Dr. Hasan Sadikin Bandung periode Oktober–Desember 2011. Penelitian ini melibatkan 51 subjek. Pemeriksaan elektrokardiografi (EKG) istirahat dilakukan pada semua subjek dan selanjutnya dilakukan penghitungan QTVI. Hampir semua subjek menderita hipertensi atau mendapat antihipertensi (94%). Gambaran EKG dengan hipertrofi ventrikel kiri didapatkan pada 37% subjek dan QTVI rata-rata subjek sebesar 0,16 (SD 0,24). Hubungan antara QTVI dan GFR dianalisis menggunakan Spearman’s rank correlation. QT variability index mempunyai hubungan yang bermakna baik dengan GFR (r=-0,816; p<0,001) maupun dengan estimated glomerular filtration rate (eGFR) (r=-0,460; p<0,001). Simpulan, terdapat hubungan sangat kuat antara QTVI dan GFR pada penderita PGK predialisis, makin rendah GFR makin panjang nilai QTVI. [MKB. 2012;44(4):193–98].Kata kunci: Kematian jantung mendadak, laju filtrasi glomerulus, penyakit ginjal kronik, QT variability indexCorrelation between QT Variability Index and Glomerular Filtration Rate in Predialysis Chronic Kidney DiseaseAbstractChronic kidney disease (CKD) patients are at increased risk for ventricular arrhythmia and sudden cardiac death (SCD). The rate of SCD in CKD patients increased as glomerular filtration rate decreased. Sudden cardiac death is generally mediated by ventricular arrhythmias associated with instability of myocardial repolarization. QT variability index (QTVI) as an index of myocardial repolarization instability is a strong predictor for fatal ventricular arrhythmias and SCD. The aim of this study was to evaluate correlation between QTVI and GFR(< 60 >mL/minute) in predialysis CKD patients. This study was done in Kidney and Hypertension Clinic of Dr. Hasan Sadikin Hospital Bandung, from October to December 2011. A total of 51 subjects were included in this study and had their resting electrocardiography (ECG) recorded and QTVI calculated, 94% had hypertension or received anti hypertension, while only 37% fulfilled the ECG criteria for left ventricular hypertrophy. We determined the correlation between QTVI and GFR using Spearman’s rank, with mean QTVI 0.16 (SD 0.24), we had strong and significant correlation between QTVI and GFR (r=-0.816, p <0.001) and moderate correlation between QTVI and estimated glomerular filtration rate (r=-0.460, p<0.001). In conclusions, there is a strong correlation between QTVI and GFR in predialysis CKD patients, the lower GFR the higher QTVI value. [MKB. 2012;44(4):193–98].Key words: Chronic kidney disease, glomerular filtration rate, QT variability index, sudden cardiac death DOI: http://dx.doi.org/10.15395/mkb.v44n4.214
Perbandingan Akurasi Berbagai Formula untuk Mengestimasi Laju Filtrasi Glomerulus pada Penderita Karsinoma Nasofaring Stadium Lanjut Sebelum Mendapat Kemoterapi Cisplatin Nissa, Camelia Khairun; Oehadian, Amaylia; Martakusumah, Abdul Hadi; Dewi, Yussy Afriani
Majalah Kedokteran Bandung Vol 47, No 1 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Cisplatin adalah obat sitotoksik dengan efektivitas tinggi dan digunakan secara luas, termasuk pada karsinoma nasofaring (KNF). Salah satu keterbatasan penggunaan cisplatin adalah nefrotoksisitas, terutama pada tubulus ginjal. Formula HARUS 15-30-60 dan HADI merupakan formula baru dalam menilai laju filtrasi glomerulus (LFG) dengan memperhitungkan  fungsi tubulus. Penelitian ini bertujuan mengetahui perbandingan akurasi formula Cockroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), HARUS 15-30-60, dan HADI dengan klirens kreatinin dalam menilai LFG pada penderita KNF stadium lanjut. Dilakukan penelitian analitik komparatif dengan rancangan potong lintang. Data diambil dari rekam medik penderita KNF yang akan mendapat kemoterapi cisplatin di Departemen Ilmu Penyakit Dalam Rumah Sakit Dr. Hasan Sadikin Bandung mulai Agustus 2012 sampai Agustus 2013. Data dianalisis menggunakan ANOVA dan uji concordance correlation coefficient (CCC). Subjek penelitian terdiri atas 70 subjek, 28 perempuan (40%) dan 42 laki-laki (60%), dengan usia rata-rata 42±12,3 tahun. Estimasi LFG berdasarkan MDRD, CG, dan HADI berbeda dengan klirens kreatinin (p<0,05), sedangkan estimasi LFG berdasarkan HARUS 15-30-60 tidak berbeda (p>0,05). Formula HARUS 15-30-60 memiliki CCC 0,401, lebih besar daripada CG (CCC=0,387), HADI (CCC=0,258), dan MDRD (0,136). Simpulan, formula HARUS 15-30-60 lebih akurat dibanding dengan formula CG, HADI, dan MDRD dalam menilai LFG pada penderita KNF stadium lanjut. [MKB. 2015;47(1):42–8]Kata kunci: Cockroft-Gault, formula HADI dan HARUS 15-30-60, klirens kreatinin, laju filtrasi glomerulus,  modification of diet in renal diseaseAccuracy Comparison of Various Formulas for Estimating Glomerular Filtration Rate in Advanced Nasopharyngeal Carcinoma Patients before Cisplatin AdministrationCisplatin is a widely used and highly effective cytotoxic agent, including for nasopharyngeal carcinoma (NPC). One of the side effects of cisplatin is nephrotoxicity, especially in tubulus. HARUS 15-30-60 and HADI are new formulas for estimating glomerular filtration rate (GFR) which also calculate tubular function. The aim of this study was to compare the accuracy of Cockroft–Gault (CG), modification of diet in renal disease (MDRD), HARUS 15-30-60 and HADI formula with creatinine clearance in assessing GFR. This was a cross-sectional study with comparative design in patients with advanced NPC before administration of cisplatin in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Data were collected from August 2012 to August 2013 and analyzed using ANOVA and concordance correlation coefficient test (CCC). There were 70 patients, consisted of 28 (40%) females and 42 (60%) males with the mean age of 42±12.3 years. LFG estimations based on MDRD, CG, and HADI were different from the creatinine clearance  (p<0.05), whereas no difference was found between HARUS 15-30-60 and creatinine clearance (p>0.05). HARUS 15-30-60 with creatinine clearance had CCC 0.401 was greater than CG (CCC=0.387), HADI (CCC=0.258), and MDRD (CCC=0.136). In conclusion, HARUS 15-30-60 formula is more accurate than CG, HADI, and MDRD formula in assessing renal function (GFR) in patients with advanced NPC. [MKB. 2015;47(1):42–8]Key words: Cockroft-Gault, creatinine clearance, estimated glomerular filtration rate, HADI and HARUS 15-30-60 formula, modification of diet in renal disease DOI: 10.15395/mkb.v47n1.396   
Co-Authors - Sugiantoro, - Amaylia Oehadian Augustine Purnomowati Camelia Khairun Nissa Chaerul Achmad Dian Qisthi, Dian Elsa Pudji Setiawati Guswan Wiwaha Yussy Afriani Dewi