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Andria Agusta
Laboratorium Fitokimia, Bidang Botani, Pusat Penelitian Biologi-LIPI
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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DIVERSITAS JALUR BIOSINTESIS SENYAWA TERPENA PAD A MAKHLUK HIDUP SEB AGAI TARGET OBAT ANTTINFEKTIF Andria Agusta
BERITA BIOLOGI Vol 8, No 2 (2006)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v8i2.2039

Abstract

Terpenoid is a fundamental cells constituent in living organisms. In living organisms, terpenoid biosynthesize via classical pathway of mevalonate and via deoxyxylulose diphosphate (DXP). The distribution patterns of both pathways are unique and specific in living organisms. In human and animal, terpenoid biosynthesize via mevalonate and IPP isomerase type I enzyme system. In plant, terpenoid biosinthesize via combination of the mevalonate and DXP pathways with IPP isomerase type I enzyme system. In parasitic protozoa like Plasmodium falciparum and in major human bacterial pathogen such as Mycobaclerium tuberculosis, Salmonella typhii and Helycobacter pylori, terpenoid biosynthesize via DXP and repeatitive IPP isomerase type II enzymesystem. The specific diversity of the terpenoid biosynthetic pathways in living organisms can use as targets for development ofnovel antiinfective drugs.
()-(2 R,3S)-DIHIDROKUERSETIN, SUATU PRODUK BIOTRANSFORMASI (-)-EPIKATEKIN OLEH JAMUR ENDOFIT Diaporthe sp. E Andria Agusta
BERITA BIOLOGI Vol 9, No 4 (2009)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v9i4.2009

Abstract

The endophytic fungus Diaporthe sp.E show a unique ability to biotransform (-)-epicatechin into (-)-(2R,3R,4R)-leucocyanidin in a semisynthetic medium. Extension of the incubation time gave a major product (-)-(2R,35)-dihydroquercetin which was identified by spectroscopic methods.
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