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All Journal Nexus Biomedika JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Katarina Bernadet Dinda Sekar Melati
Faculty of Medicine, Sebelas Maret University
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hubungan Antara Onset Terjadinya Menopause Dengan Status Perkawinan Melati, Katarina Bernadet Dinda Sekar
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (76.8 KB)

Abstract

Background: Elderly women will experience a condition due to the aging process called menopause. The onset of menopause in one woman to the others is diverse depending on its modifying factors. Marital status is suspected as one of modifying factors besides the environmental factors like pollution and radiation, smoking, obesity, numbers of children and chemotherapy. Bogor, one of the city in West Java, has 452 women with unmarried status which are on the edge of menopause. This purpose of this research is to understand the correlation between onset of menopause and marital status. Methods: This research used analytical observational studies with cross sectional approach by using purposive sampling technique which had been done in June until July 2011. The number of samples was 60 women coming from six region of Bogor who were appropriate to the required inclusion criteria. The data was collected through interviewing and answering the questionnaire by respondent. The data as a result were analyzed statistically by Chi Square analysis by using SPSS 17.0. Results: The result of Chi Square analysis was 4,286 as X2 count. This result was more than X2 table for the standard of significance 5% and the degree of freedom 1, which was 3,841 (p<0,05). From counting of Odds Ratio (OR) the result was 3. Conclusions:. There was a relation between onset of menopause and marital status. Unmarried woman would face early menopause onset three times higher than the married ones. Keywords: Onset of Menopause  – Marital Status 
The Effectiveness of Meloxicam Adjuvant Therapy against Negative Symptoms and Neutrophil Lymphocyte Ratio (NLR) in Schizophrenic Patients Melati, Katarina Bernadet Dinda Sekar; Hardaetha, Adriesti; Kusuma, Wijaya
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.57-62

Abstract

Highlights:1. The NLR value can show the role of neuroinflammation in schizophrenic patients.2. Meloxicam as adjuvant therapy can improve negative symptoms and changes in the NLR in schizophrenic patients. AbstractIntroduction: Neutrophil-lymphocyte ratio is a simple and affordable marker of inflammation that has recently been widely used to assess systemic inflammation in psychiatric patients. This study aimed to determine and analyze the effectiveness of meloxicam as adjuvant therapy to improve negative symptoms and changes in the neutrophil-lymphocyte ratio (NLR) in schizophrenic patients. Methods: This was a quasi-experimental study using a single-blind, pretest–post-test design. Subjects were determined using a purposive sampling technique based on inclusion criteria. This study examined 34 samples and divided them into two groups. The treatment group consisted of 17 subjects who received adjuvant therapy with meloxicam 15 mg/day for 4 weeks and 17 subjects in the control group. Data collection was obtained from medical records, interviews, field notes, positive scale, negative scale, and general psychopathology scale (PANSS) assessment sheets, and blood NLR examinations. Data analysis used SPSS 25.0.Results: The negative subscale PANSS score in the treatment group decreased lower than in the control group, with p-value = 0.640. However, the decrease in NLR values was more significant in the treatment group than in the control group, with p-value = 0.094. There was a decrease in the negative subscale PANSS scores and clinical NLR scores, but it was not statistically significant.Conclusion: Adjuvant therapy with Meloxicam, given once a day for four weeks, had an effect on decreasing the negative subscale PANSS score and NLR scores for schizophrenic patients at Dr. Arif Zainudin Regional Mental Hospital (RSJD), Surakarta, clinically, but it was not statistically significant.
Co-Authors Hardaetha, Adriesti Wijaya Kusuma