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Mochamad Anwar Mochamad Anwar
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Comparative study of the endocrine functions in Norplant vs Depoprovera acceptors Mochamad Anwar, Mochamad Anwar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 02 (1994)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.554 KB)

Abstract

The steroidal contraceptive agents are highly predictable in preventing pregnancy, however, all currently used synthetic progestogens have certain potential side effects. These side effects may be due to either the direct actions of the synthetic steroids or the indirect actions through the womens own endocrine system.The objective of the study is to evaluate potential alterations of the endocrine functions in women using Norplant compared to injectable contraceptive method.The study was conducted in a cohort study by recruiting 25 women in each group receiving either Norplant or Depoprovera contraceptive method voluntarily. Six months after entering the study 10 ml of blood was taken from the cubits] vein and follicle stimulating hormone (FSH) , luteini zing hormone (LH), prolactine (PRL), progesterone (P), oestradiol (E2), total testosterone (r), free testosterone (FT) and sex hormone binding globulin (SHBG) were measured using radioimmunoassay.The mean of SHBG level in Norplant (29.44 ± 9.85 nmol/l) is statistically, lower (p421.001) compared to Depoprovera acceptors (50.64 ± 21.29 nmol/l), however, they were still in the normal range. The means of total testosterone and free testosterone level were higher in Norplant group, however, they were not statistically different (p = 0,391 and 0.182 respectively). No androgenicity symptoms were clinically found in both groups. Either Norplant or Depoprovera lowering the secretion of progestogen and oestrogen, indicated that the alterations of endocrine function occured more frequently in the level of target organ (ovary) rather than in the level of hypophysis or hypothalamus. These findings were also confirmed by the mean levels of FSH, LH and prolactine which were also in the normal range.It is concluded, that there were no potential alterations of the endocrine functions in women using either Norplant or Deprovera especially in androgenicity. The influence of both progestogen contraceptive methods were greater on the level of target organ.Key words : contraception-Norplant-Depoprovera -radioimmuno assay-blood
Pregnancy after unilateral operation an androblasicuna Mochamad Anwar, Mochamad Anwar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 04 (1992)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.827 KB)

Abstract

Androblastoma is a rare semimalignant ovarian tumor which occurs most frequently during the reproductive years and is assumed to arise from sexually ambivalent cells noted in the ovary of the 6-7 weeks embryo or to be of teratoid origin. The excessive secretion of testosteron will occur and lead to masculinism, while androgens will suppress normal ovarian function and cause the sign of virilization. A 3-years subferdIc case was a 27 year-old-woman with typical syndrome of androblastoma manifested by virilization and defeminization. The testosteron concentration was 700 ng/dl, prolactin: 8,4 p.g/1, Barr body drumstick (+), while the chromosomal analysis indicated female genotype (46 XX). Simple oophorcctomy was done, the size of the left ovarian tumor was 9 x 7 x 8 cm, encapsulated and there was no adhesion. The uterus and adnexa were normal. The pathological result was malignant. Alkeran cytostatic treatment was given in 5 series of 12,5 mg orally. However, the pregnancy occurred during the treatment. The patient was then managed carefully as a routine procedure without and-cancer drugs anymore. The baby was born normally without any congenital anomaly. The signs of either virilism or masculinism decreased. Hormonal examination showed a normal level of testosteron.Key Words: infertility - androblastoma - cytostatics - ovarian tumor - virilization
Comparative study of the endocrine functions in Norplant vs Depoprovera acceptors Mochamad Anwar Mochamad Anwar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 02 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.554 KB)

Abstract

The steroidal contraceptive agents are highly predictable in preventing pregnancy, however, all currently used synthetic progestogens have certain potential side effects. These side effects may be due to either the direct actions of the synthetic steroids or the indirect actions through the women's own endocrine system.The objective of the study is to evaluate potential alterations of the endocrine functions in women using Norplant compared to injectable contraceptive method.The study was conducted in a cohort study by recruiting 25 women in each group receiving either Norplant or Depoprovera contraceptive method voluntarily. Six months after entering the study 10 ml of blood was taken from the cubits] vein and follicle stimulating hormone (FSH) , luteini zing hormone (LH), prolactine (PRL), progesterone (P), oestradiol (E2), total testosterone (r), free testosterone (FT) and sex hormone binding globulin (SHBG) were measured using radioimmunoassay.The mean of SHBG level in Norplant (29.44 ± 9.85 nmol/l) is statistically, lower (p421.001) compared to Depoprovera acceptors (50.64 ± 21.29 nmol/l), however, they were still in the normal range. The means of total testosterone and free testosterone level were higher in Norplant group, however, they were not statistically different (p = 0,391 and 0.182 respectively). No androgenicity symptoms were clinically found in both groups. Either Norplant or Depoprovera lowering the secretion of progestogen and oestrogen, indicated that the alterations of endocrine function occured more frequently in the level of target organ (ovary) rather than in the level of hypophysis or hypothalamus. These findings were also confirmed by the mean levels of FSH, LH and prolactine which were also in the normal range.It is concluded, that there were no potential alterations of the endocrine functions in women using either Norplant or Deprovera especially in androgenicity. The influence of both progestogen contraceptive methods were greater on the level of target organ.Key words : contraception-Norplant-Depoprovera -radioimmuno assay-blood
Pregnancy after unilateral operation an androblasicuna Mochamad Anwar Mochamad Anwar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 04 (1992)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.827 KB)

Abstract

Androblastoma is a rare semimalignant ovarian tumor which occurs most frequently during the reproductive years and is assumed to arise from sexually ambivalent cells noted in the ovary of the 6-7 weeks embryo or to be of teratoid origin. The excessive secretion of testosteron will occur and lead to masculinism, while androgens will suppress normal ovarian function and cause the sign of virilization. A 3-years subferdIc case was a 27 year-old-woman with typical syndrome of androblastoma manifested by virilization and defeminization. The testosteron concentration was 700 ng/dl, prolactin: 8,4 p.g/1, Barr body drumstick (+), while the chromosomal analysis indicated female genotype (46 XX). Simple oophorcctomy was done, the size of the left ovarian tumor was 9 x 7 x 8 cm, encapsulated and there was no adhesion. The uterus and adnexa were normal. The pathological result was malignant. Alkeran cytostatic treatment was given in 5 series of 12,5 mg orally. However, the pregnancy occurred during the treatment. The patient was then managed carefully as a routine procedure without and-cancer drugs anymore. The baby was born normally without any congenital anomaly. The signs of either virilism or masculinism decreased. Hormonal examination showed a normal level of testosteron.Key Words: infertility - androblastoma - cytostatics - ovarian tumor - virilization
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