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Mansyur Arif
Post Graduate Program in Clinical Biochemistry, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, Makassar
Biochemistry, Genetics & Molecular Biology Public Health

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Correlation of Urine Albumin/Creatinine Ratio (UACR), High Sensitivity C-Reactive Protein (hsCRP) and N-Terminal Pro Brain Natriuretic Peptide (NT-proBNP) with Atherosclerosis (OxLDL) in Centrally Obese Men Nancy Pakpahan; Mansyur Arif; Ilhamjaya Patellongi
The Indonesian Biomedical Journal Vol 3, No 1 (2011)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v3i1.132

Abstract

BACKGROUND: Obesity is closely associated with atherosclerosis risk and cardiovascular disease. Novel cardiovascular risk biomarkers such as Urine Albumin/Creatinine Ratio (UACR), High Sensitivity C-Reactive Protein (hsCRP) and N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) have been observed to predict cardiovascular disease in the general population. The aim of this study was to observe the correlation of UACR, hsCRP and NT-proBNP with atherosclerosis (OxLDL) in centrally obese men.METHODS: The study was observational with a cross sectional design done on 76 male subjects aged 30–50 years with central obesity and mean of age of 37 years. Urine albumin was determined by PEG enhanced immunoturbidimetric assay, urine creatinine by Jaffe without deproteinase, hsCRP by chemiluminescent immunometric assay, NT-proBNP by electrochemiluminescence (ECLIA) and OxLDL by ELISA.RESULTS: There was significant correlation between hsCRP and OxLDL (r=0.230, p=0.046). There was no significant correlation between UACR and OxLDL (r=-0.138, p=0.236), neither between Log NT-proBNP and OxLDL (r=-0.173, p=0.136).CONCLUSIONS: Atherosclerosis was significantly correlated with hsCRP (low grade inflammation).KEYWORDS: NT-proBNP, UACR, hsCRP, OxLDL, atherosclerosis
Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome Waode Nurfina; Irawan Yusuf; Mansyur Arif
The Indonesian Biomedical Journal Vol 2, No 3 (2010)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v2i3.127

Abstract

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane
Co-Authors Ilhamjaya Patellongi Irawan Yusuf Nancy Pakpahan Waode Nurfina