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All Journal Indonesia Chimica Acta
Andi Fikrah Auliya Pamenta
Universitas Hasanuddin
Chemical Engineering, Chemistry & Bioengineering

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α-Glucosidase Inhibitory Activity Of Cucurbitane Derivate Isolated From Methanol Extract Of Momordica charantia L. Leaves Andi Fikrah Auliya Pamenta
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 12, No 2: December 2019
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v12i2.8341

Abstract

Cucurbitane derivative has been isolated from methanol extract of the leaves of bitter melon (Momordica charantia). Purification of methanol extract using vacuum column chromatography method using n-hexane: ethyl acetate as the mobile phase was obtained a white powder isolate. This isolate was elucidated to obtain chemical structures based on spectroscopic data (FT-NMR, FT-IR, and LC-MS/MS) and resulted a cucurbitane derivate, namely momordicine I. The MeOH extract and the isolate were evaluated for α-glucosidase inhibitory effect. Both MeOH extract and momordicine I showed moderate activities with %inhibition 27.34% and 15.79 % at 100 µg/mL repectively.
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