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All Journal Science and Technology Indonesia Jurnal Permata Indonesia Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine

Indah Solihah

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Author-ID : 3234302

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Articles

Antidiabetic Activity Test of Ethanolic Seri Leave’s (Muntingia Calabura L.) Extract in Male Rats Induced by Alloxan Herlina Herlina; Annisa Amriani; Indah Solihah; Rizky Sintya
Science and Technology Indonesia Vol. 3 No. 1 (2018): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Antidiabetic activity test of ethanol extract of seri leave (Muntingia calabura L.) rats induced by alloxan has been done. Male wistar albino rats are used as animal models which divided into 6 groups, normal group (aquadest), negative control group (Na CMC 0,5%), positive control group (glibenclamide 0,43 mg/200 gBB), and 1, 2, and 3 treatment groups (ethanol extract of seri leave 65, 130, dan 260 mg/kgBB). Rats blood glucose level after induced intraperitoneally by alloxan 130 mg/kgBB can be stated as diabetes when >200 mg/dL. Preprandial blood glucose levels are measured using DTN-410-K photometer, on day 0, 5, 10, and 15. The average result of AUC0-15 and percentage of decreasing blood glucose level for positive control group are 2732,5 and 37,43%, and 3 treatment groups (65 mg/kgBB, 130 mg/kgBB, and 260 mg/kgBB) 3105 and 28,90%; 2962,5 and 32,16%; 2810 and 35,66%. This point indicated that the ethanol extract of seri leave has an antidiabetic activity and there is no significant difference compared with glibenclamide (p<0,05). Percentage of blood glucose decrease level the third treatment group there is no significant difference compare with positive control group. According to the relation between percentage of blood glucose decrease level with dose, value of ED50 of ethanol extract of seri leave is 692,424 mg/kgBB.

Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil Herlina Herlina; Budi Untari; Indah Solihah; Merie Santia
Science and Technology Indonesia Vol. 4 No. 1 (2019): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p>0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW

UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN TAHONGAI (Kleinhovia hospita L.) MENGGUNAKAN METODE RAT PAW EDEMA Indah Solihah; Herlina; Oktia Charmila
Jurnal Permata Indonesia Volume 8, Nomor 2, November 2017
Publisher : Politeknik Kesehatan Permata Indonesia Yogyakarta

Tahongai (Kleinhovia hospita L.) telah banyak digunakan dalam pengobatan tradisional diIndonesia oleh suku Komering, Sumatera Selatan untuk mengobati penyakit yang berhubungandengan inflamasi, seperti tumor, polip, jerawat, dan nyeri haid. Senyawa aktif yang berhasildiisolasi dari daun tahongai yaitu astragalin, eleutherol, skopoletin, (Arung et al, 2012),kuersetin, rutin, dan kaemferol (Ramesh & Subramanian, 1984). Senyawa flavonoid telah ditelitimemiliki aktivitas antiinflamasi (Middleton,2000). Penelitian ini bertujuan untuk mengetahuiaktivitas antiinflamasi dari ekstrak etanol daun tahongai secara in vivo. Pengujian antiiinflamasidilakukan menggunakan metode rat paw edema pada 25 ekor tikus putih jantan galur Wistaryang dibagi menjadi 5 kelompok. Kelompok I sebagai kontrol negatif diberikan Na CMC 1%,kelompok II diberikan Na diklofenak sebagai kontrol positif, kelompok III, IV dan V diberikanekstrak 250, 500, dan 750 mg/kgBB. Hasil penelitian menunjukkan bahwa pemberian ekstraketanol daun tahongai pada dosis 500 dan 750 mg/kgBB secara oral memiliki aktivitasantiinflamasi yang tidak berbeda signifikan (p >0,05) terhadap kontrol positif. Dosis efektif(ED50) dihitung berdasarkan persen inhibisi rata-rata edema tikus, didapatkan nilai ED50 ekstraketanol daun tahongai sebesar 605,04 mg/kgBB.

Identifikasi Metampiron Dalam Jamu Pegal Linu Yang Beredar Di Kota Palembang Indah Solihah; Budi Untari; Lenta Haliani Putri
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 8 No. 2 (2021): Jurnal Kesehatan dan Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

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Jamu pegal linu merupakan obat tradisional yang banyak dikonsumsi oleh masyarakat. Pencampuran jamu dengan bahan kimia obat (BKO) sering dilakukan untuk menjadikan jamu tersebut semakin berkhasiat lebih cepat. BKO yang umumnya ditemukan dalam jamu pegal linu adalah golongan AINS, salah satunya metampiron. Identifikasi kandungan BKO metampiron dilakukan menggunakan metode kromatografi lapis tipis (KLT), dengan mengamati sebanyak 21 sampel jamu pegal linu yang beredar di kota Palembang. Pengujian menggunakan fase diam plat KLT GF254 dan fase gerak campuran etil asetat p.a. dengan metanol p.a. (7:3). Hasil elusi menunjukkan bahwa sampel 1 positif mengandung BKO metampiron, karena mempunyai harga faktor retensi yang sama dengan baku pembanding yaitu sebesar 0,457. Kadar metampiron dalam sampel 1 diukur menggunakan spektrofotometer UV-Vis, dengan pelarut asam asetat glasial 0,5% dalam akuades. Hasil pengukuran kadar BKO metampiron dalam sampel 1 diperoleh sebesar 1,263%. Hasil penelitian menunjukkan bahwa validasi terhadap metode analisis ini telah memenuhi syarat % CV sebesar 4,11289% dan nilai R sebesar 0,9986, dengan LOD sebesar 2,07933 ppm dan LOQ sebesar 6,93110 ppm.Kata Kunci: jamu pegal linu, bahan kimia obat, metampiron.

Co-Authors Annisa Amriani Budi Untari Herlina Herlina Herlina Lenta Haliani Putri Merie Santia Oktia Charmila Rizky Sintya

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