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All Journal BALI MEDICAL JOURNAL (BMJ) INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES
and J. K. Mukkadan
Research Director, Little Flower Medical Research Centre, Angamaly
Medicine & Pharmacology

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ANTI DIABETIC EFFECT OF ORAL ADMINISTRATION OF CINNAMON IN WISTAR ALBINO RATS Kumar, S. S.; Mukkadan, and J. K.
BALI MEDICAL JOURNAL Vol 2 No 3 (2013): Vol.2, No.3, September-December 2013
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: The present study was undertaken with an objective to observe effectiveness of oral administration of cinnamon extract to hyperglycemic induced rats using alloxan. Male and female Wistar Rats were injected with alloxan to induce hyperglycemia. Methods: This is an experimental study to determine whether cinnamon has an ability to combat hyperglycemic rats. Blood glucose was estimated by GOD-PAP method using diagnostic kit supplied by Agappe diagnostics, Maharashtra. Results: The present experimental study provides further evidence that oral administration of Cinnamon extract for 21 days produced a significant decrease in the blood glucose level in the model of alloxan induced diabetes rats. Conclusion: From this study, we can conclude that the oral administration of Cinnamon extracts have beneficial effect on blood glucose levels. However further pharmacological and biochemical investigations will clearly elucidate the mechanism of action and helpful in projecting these plant extracts as a therapeutic target in diabetes research.
ORAL ADMINISTRATION OF PEPPERMINT IN WISTAR ALBINO RATS: Memory Boosting and Regaining Jasira, M.; Sai-Sailesh, K.; Mukkadan, and J. K.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 1 (2013): IJBS Vol.7 No.1 January-June 2013
Publisher : Udayana University

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Abstract

The studies on peppermint aroma fluence on cognition are numerous. However the knowledge about oral consumption of peppermint and cognition was inadequate. Hence the present study was undertaken to find out the effect of oral administration of peppermint spices in memory boosting and memory regaining on adult wistar rats. Here we investigate the influence of oral intake of peppermint on behavioral task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. We have observed significant memory boosting and memory regaining effects of peppermint when administered orally. This effect may be due to improvement of the blood flow to the brain and increasing the concentration power.  Hence we recommend further research in this area by investigating compound metabolism to optimize quantification of memory performance following peppermint ingestion.
Co-Authors K. Sai-Sailesh M. Jasira S. S. Kumar