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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Jamu Indonesia Community Empowerment
Nur Ismiyati
Politeknik Kesehatan Bhakti Setya Indonesia, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Education Medicine & Pharmacology Public Health Social Sciences Other

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Cytotoxic Activity of 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone on Colon Cancer Cell WiDr Nur Ismiyati; Yuli Puspito Rini; Andi Eko Wibowo; Ratna Asmah Susidarti
Indonesian Journal of Cancer Chemoprevention Vol 6, No 1 (2015)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev6iss1pp12-15

Abstract

Colon cancer is one of the most common death-caused cancer. The high mortality rate indicates that chemotherapy has not overcome cancer disease. Strategies and development of colon cancer treatment should be pursued. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone is the 2ʹ,5ʹ-dihydroxychalcone derivative, of which the B ring was substituted with 2-pyridine ring. Chalcone and its derivatives have been reported to have several biological activities, such as cytotoxic, anti-inflammatory, antiHIV, and as a tyrosine kinase inhibitor. The objectives of this research was to determine the cytotoxic activity on WiDr colon cancer cells of 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone. Cytotoxic activity was measured using MTT assay. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone inhibited WiDr cell growth with the IC50 of  16 µM. Morphology of WiDr cell showed that compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone inhibited cell growth in dose dependent.Keywords:  compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone, WiDr colon cancer cell line, cytotoxic activity
Antibacterial Activity of Ethanolic Extract, n-Hexane Fraction, and Chloroform Fraction of Binahong Leaves (Anredera Cordifolia) on Escherichia Coli and its Phytochemical Screening Pramita Yuli Pratiwi; Ana Mardiyaningsih; Nur Ismiyati; Hery Setiyawan
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.207

Abstract

Binahong leaves (Anredera cordifolia (Ten.) Steenis) are known to contain antibacterial activity compounds. The compounds contained in binahong leaves include flavonoids, alkaloids, saponins, and tannins. Escherichia coli is a gram-negative bacteria that often causes infections such as diarrhea. The purpose of this study was to determine the effect of ethanolic extract, n-hexane fraction, and chloroform fraction of binahong leaves on the growth of Escherichia coli bacteria and its phytochemical screening This research used ethanolic extract, hexane fraction and chloroform fraction of binahong leaves against Escherichia coli bacteria with concentrations of 12.5, 25 and 50% The positive control was chloramphenicol and the negative control was DMSO The method used disk diffusion technique, marked the presence of clear areas around the paper disc that showed an obstacle to bacterial growth phytochemical screening of alkaloids, flavonoids, saponins and tannins using a test tube. The result showed antibacterial activity against the growth of Escherichia coli with the diameter of the inhibition zone at concentrations of 12.5, 25, and 50%, namely the hexane fraction of 8.16; 9.73 and 12.93 mm. At the chloroform fraction 7.67; 8.47 and 9.87 mm. and the ethanolic extract of 7.33; 9.95 and 13.32 mm. The result of the largest inhibition zone was the ethanolic extract of binahong leaves with a concentration of 50%. The results of phytochemical screening using a test tube showed that the compounds contained in the ethanolic extract were flavonoids, alkaloids, saponins, and tannins.
Posyandu cadre training in utilizing information systems to manage elderly medical record data Hendra Rohman; Nur Ismiyati; Iramie Duma Kencana Irianto
Community Empowerment Vol 7 No 11 (2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.7778

Abstract

Posyandu activities for the elderly are carried out regularly in RW 29 and RW 30 Padukuhan Tegalwaras, Sariharjo, Kapanewon Ngaglik, Sleman, Yogyakarta. Bougenvile Posyandu cadres carry out the process of recording medical record data on paper and books. Data that is difficult to read and unsustainable needs to be changed. The aim of this program is to train all posyandu cadres in managing elderly data through a web browser. The implementation method is an analysis of information system needs, counseling related to health information systems, technical training of equipment used, assistance in the use of information systems, monitoring and evaluating the results of all activities by analyzing the ability to use posyandu information systems every month. As a result, on the system there are main menus, namely registration, inspection, print reports, graphics, restore data, user data, my profile, materials, and activities. The existence of an information system for the elderly posyandu is able to increase the knowledge and skills of cadres in managing data using a web-based information system.
Optimizing apothecary through medicinal plant cultivation and education of elderly posyandu cadres in Tegalwaras Nur Ismiyati; Hendra Rohman; Purwanto Purwanto; Ronggo Nurcahyo; Iramie Duma Kencana Irianto
Community Empowerment Vol 8 No 8 (2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.9025

Abstract

As people age, the prevalence of degenerative diseases increases. These diseases can reduce the quality of life and often cause fatal effects, and this happens a lot in Tegalwaras hamlet. Treatment with modern medicine sometimes causes problems such as relatively expensive prices and dangerous side effects so alternatives such as herbal medicines are needed. This community service aims to increase the knowledge of Posyandu Lansia cadres in Tegalwaras about herbs as a therapy for degenerative diseases through counseling and planting medicinal plants. The method of implementation is the preparation stage, counseling, planting medicinal plants, monitoring and evaluation. The results of the program showed an increase in knowledge of 50% after the counseling was carried out.
Co-Authors Ana Mardiyaningsih Andi Eko Wibowo Hendra Rohman Hery Setiyawan Iramie Duma Kencana Irianto Pramita Yuli Pratiwi Purwanto Purwanto Ratna Asmah Susidarti Ronggo Nurcahyo Yuli Puspito Rini