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Indra Wijaya
Faculty of Medicine Diponegoro University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Expression of p53 and Bcl2 Mammary Adenocarcinoma in C3H Mice Administered With Salvia miltiorrhizae Bunge root extract Liza Suryani Dewi; Noor Widjayahadi; Indra Wijaya
Journal of Biomedicine and Translational Research Vol 2, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.736 KB) | DOI: 10.14710/jbtr.v2i2.25

Abstract

Background: Breast cancer is on the first or second most malignancy in many places around the world. The incidence of breast cancer was increasing, also in Indonesia. Prevention and treatment of breast cancer have not been satisfactory, since patients and medical practitioners are searching for other therapeutic and preventive agents. Salvia miltiorrhizae Bunge roots is one of the therapeutics agent used in traditional medicine have been studied in foreign country.Objective: To prove the p53 and Bcl2 expression in C3H mice mammary adenocarcinoma using multilevel doses of the Salvia miltiorrhizae Bunge roots extract. Methods :The study is a randomized post-test only controlled group design. A total of 18 adenocarcinoma mice, divided into 3 groups. The first group was administered with 60mg/KgBW/day and the second group was given by 180mg/KgBW/day, for 21 days. All mice were terminated on day 22nd. The p53 and Bcl2 expressions were analyzed using Allred score, statistically analized by Kruskal Wallis followed by Post-Hoc Mann Whitney U test.Results :Immunohistochemistry staining shows the p53 expressions have been increased between groups, but Bcl2 were decreased. The Kruskal-Wallis and Post-Hoc Mann Whitney U test are significantly difference between groups.Conclusion :All of the p53 and Bcl2 expressions between groups are significantly differences.
Expression of TTF-1 and CK-7 in the Diagnosis of Pleural Effusion Cytology Suspected Lung Adencarcinoma Patricia Diana Prasetiyo; Ika Pawitra; Indra Wijaya
Journal of Biomedicine and Translational Research Vol 1, No 1 (2015): April 2015
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.811 KB) | DOI: 10.14710/jbtr.v1i1.49

Abstract

Background : Lung cancer is the mayor disease that cause death worldwide including Indonesia especially Nonsmall cell lung cancer (NSCLC) consisting of adenocarcinoma, squamus carcinoma (SqCCA) and large cell carcinoma. Incidency of lung adenocarcinoma continues to rise recently about 40% of all NSCLC.Methods : Descriptive observational study design. The study population included the patients who were hospitalized at Kariadi central hospital in Semarang and had thorax X-ray or CT scan of thorax with a diagnosis of suspected lung malignancy, at the period of January 2012 – 2013. The variables assessed are expression of TTF-1 and CK-7.Result : A total of 20 samples subjected to Pearson correlation test with result of p value = < 0,001 and r = 0,867. Presentation of the highest expression TTF-1 in the all study sample is Adenocarcinoma 73,3% and highest expression CK-7 is also Adenocarcinoma 68,6%.Conclusion : Immunocytochemistry of TTF-1 and CK-7 can be used to determine Adenocarcinoma malignancy on cytological sample of suspected malignant pleural effusion
Co-Authors Ika Pawitra Liza Suryani Dewi Noor Widjayahadi Patricia Diana Prasetiyo