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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research
Fanti Saktini
Department Of Histology, Faculty Of Medicine, Diponegoro University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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JAK2 V617F Analysis in Indonesian Myeloproliferative Neoplasms Patients Fanti Saktini; Santosa Santosa; Sultana MH Faradz
Journal of Biomedicine and Translational Research Vol 1, No 2 (2015): December 2015
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.257 KB) | DOI: 10.14710/jbtr.v1i2.63

Abstract

Background : Three subtypes of myeloproliferative neoplasms (MPNs): Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) showed overlapping phenotype. There has been no specific cytogenetic marker identified in these subtypes. JAK2 V617F mutation prevalence in Caucasian MPNs was first reported as 97% in PV, 57% in ET, and 50% in PMF.Objective: This study was done to define the prevalence of JAK2 V617F mutation and to identify cytogenetic markers in MPNs.Methods : The study design was cross-sectional. Patients who were admitted to Dr. Kariadi Hospital with clinical diagnosis of MPNs were referred for bone marrow cytogenetic analysis in Telogorejo Hospital. JAK2 V617F mutation was tested for using Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) from peripheral blood vein. Clinical data were secondary data retrieved from hospital medical records.Results :  There was no cytogenetic abnormality found in all MPNs patients. The prevalence of JAK2 V617F mutation in MPNs patients was 73,68%. Mutation prevalence distribution in each subtypes were 100% in PV, 63,6% in ET and 100% in PMF. Conclusion : Chromosomal abnormality was not found using conventional cytogenetic analysis. More sensitive methods might elucidate submicroscopic chromosomal abnormalities in these patients. The prevalence of JAK2 V617F mutation was comparable with studies in Caucasian. It is recommended that JAK2 V617F testing should be incorporated in the management therapy of MPNs in Indonesia.
THE RELATIONSHIP OF ACADEMIC PROCRASTINATION WITH STRESS, ANXIETY, AND DEPRESSION DURING THE COVID-19 PANDEMIC IN STUDENTS OF THE MEDICAL STUDY PROGRAM, FACULTY OF MEDICINE, UNDIP Melania Tiara Cahyaratri; Fanti Saktini; Hang Gunawan Asikin; Tanjung Ayu Sumekar
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33244

Abstract

Background: Academic procrastination is defined as a learner's tendency to delay learning-related activities, which in many cases eventually causes anxiety and stress. Studying at home tends to cause a feeling of having a lot of free time, eventually postponing work. Students who often procrastinate tend to experience anxiety and depression more often than students who do not procrastinate.Aim: To prove the relationship between academic procrastination and stress, anxiety, and depression due to the COVID-19 pandemic.Method: This research was a cross-sectional study with 184 respondents. The research was conducted in November 2021. The respondents were UNDIP medical students batch 2020. The questionnaires used were the Procrastination Academic Scale for Student (PASS) and Depression, Anxiety, Stress Scale-21 (DASS-21). Data were taken from the questionnaire after the respondents agreed to the informed consent and were analyzed using the Spearman correlation test.Results: As many as 70,1% of respondents were female. Almost 50% of students have a high level of procrastination. A total of 21.7% of students experienced severe to very severe stress, 55.4% experienced severe to very severe anxiety, and as many as 50.4% experienced severe to very severe depression. The level of academic procrastination was positively correlated with stress levels (r=0.468, p<0.001), anxiety levels (r=0.468, p<0.001), and depression levels (r=0.401, p<0.001).Conclusion: Academic procrastination with stress, anxiety, and depression during the COVID-19 pandemic has a significant relationship with a moderate positive correlation.Keywords: Procrastination ; Stress ; Anxiety ; Depression ; COVID-19 Pandemic.
The Relationship Between Academic Procrastination and Sleep Quality of Students of Medical Study Program, Faculty of Medicine, Diponegoro University During the COVID-19 Pandemic Athaya Zayyan Pusparini; Fanti Saktini; Hang Gunawan Asikin; Tanjung Ayu Sumekar
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 3 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33242

Abstract

Background: The COVID-19 pandemic requires the government to take policies by establishing online learning. Online learning has significantly provided changes to students' daily activities, thus resulting in academic procrastination. Academic procrastination is defined as an act of postponing academic activities that may lead to decreased academic performance, increased physical, emotional, mental problems, and unhealthy sleep patterns. Sleep is referred to as a crucial activity of daily routines, and poor sleep quality may contribute to negative impacts on academic success. Aim: To evaluate the relationship between procrastination and sleep quality for students of the Medical Study Program, Faculty of Medicine, Diponegoro University, during the COVID-19 pandemic. Method: This research used a cross-sectional design. Subsequently, 84 active students of the Faculty of Medicine, Diponegoro University, Class of 2020, were found to meet the research criteria, agreed to the informed consent, and filled out the complete questionnaire. The statistical test used was Spearman's test analysis. Results: Referring to the results obtained, there was no significant relationship between academic procrastination and sleep quality for students during the COVID-19 pandemic. Moreover, 39 (46.4%) students were identified as having a high level of academic procrastination. Meanwhile, the majority of students with poor sleep quality during the COVID-19 pandemic was amounted to 52 (61.9%). Conclusion: There was no significant relationship between academic procrastination and sleep quality for students of the Medical Study Program, Faculty of Medicine, Diponegoro University, during the COVID-19 pandemic.
Co-Authors Athaya Zayyan Pusparini Hang Gunawan Asikin Melania Tiara Cahyaratri Santosa Santosa Sultana MH Faradz Tanjung Ayu Sumekar