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All Journal The Journal of Pure and Applied Chemistry Research
Martin Luther Silubun
The Center of Narcotics Laboratory of National Narcotics Board Republic of Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS) Rieska Dwi Widayati; Tanti Tanti; Erlana Nindya Maulida; Martin Luther Silubun
The Journal of Pure and Applied Chemistry Research Vol 9, No 2 (2020): Edition May-August 2020
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2020.009.02.537

Abstract

Synthetic cannabinoids are commonly known as Gorillas Tobacco, Hanomans Tobacco or Ganeshas Tobacco in Indonesia. Those products are camouflaged as a tobacco related to the number of smokers in Indonesia. The 5F-ADB (5F-MDMB-PINACA) has become an issue since 2016. It was undetectable by conventional drug testing methodology such as immunoassay method. GC-MS as a routine method analysis is not recommended also for detecting the metabolites from biological specimen with low concentration. The paper report LC-HRMS based method for identification of 5F-ADB and its metabolites in urine sample. Various of volume injections (1, 3, and 6 µL) was studied. Sample was acidified with concentrate of HCl, then undergo extraction with EXtrelut® Column NT3 prior to LC-HRMS analysis. The full method was operated for MS/dd-MS2 identification. The 5F-ADB and its ester hydrolysis metabolite, 5F-ADB metabolite 7 (C19H27FN3O3+) was detected in urine sample.
Co-Authors Erlana Nindya Maulida Rieska Dwi Widayati Tanti Tanti