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Dennis C. J.Waalboer
Radboud University Nijmegen, Institute for Molecules and Materials, Netherlands.
Astronomy Chemistry Earth & Planetary Sciences Mathematics Physics

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Synthesis and Biological Activity of Novel Platencin Derivatives Dennis C. J.Waalboer; Floris P. J.T. Rutjes
Journal of Mathematical and Fundamental Sciences Vol. 43 No. 2 (2011)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/itbj.sci.2011.43.2.3

Abstract

The biological mode of action of platencin, a potential lead molecule for a new class of antibiotics, is detailed. Furthermore, enantiopure syntheses of several platencin derivatives are described, of which the core structure can be accessed in two exceedingly simple steps from commercially available starting materials. Furthermore, the antibiotic properties of the derivatives was evaluated.
Co-Authors Floris P. J.T. Rutjes