Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Folia Medica Indonesiana AKSONA
Mohammad Saiful Islam
Departemen Neurologi, Fakultas Kedokteran, Universitas Airlangga; RSUD Dr. Soetomo, Surabaya, Indonesia
Medicine & Pharmacology Neuroscience Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Analysis of Differences of Serum Thromboxane B2 Level after Taking Acetosal in Acute Thrombotic Stroke with Diabetes Mellitus and Non-Diabetes Mellitus Nur Hadiyanti; Didik Hasmono; Mohammad Saiful Islam
Folia Medica Indonesiana Vol. 54 No. 1 (2018): March
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.965 KB) | DOI: 10.20473/fmi.v54i1.8053

Abstract

Endothelial dysfunction and vascular injuries are the early processes in thrombogenesis leading to thrombotic stroke. These processes trigger platelet activation characterized by synthesis of Thromboxane A2, potent agonist in platelet aggregation. Acetosal (ASA) 100 mg usually given to thrombotic stroke patients exerts its pharmacological effect by inhibition of TxA2 synthesis, thus could prevent thrombus formation. Diabetes mellitus (DM) as risk factor of thrombotic stroke exhibits an increase in TxA2 synthesis. It is not known whether ASA 100 mg could inhibit TxA2 adequately in diabetic patients. This study aimed to analyze the differences of serum TxA2 level, which was measured by serum TxB2 level as stabile metabolite of TxA2, after taking ASA 100 mg in diabetic and non-diabetic thrombotic stroke patients. This prospective observational study was held in Neurology Department of Dr. Soetomo Hospital, Surabaya. Total 27 patients, consisted of 15 patients with DM and 12 patients with non-DM were enrolled. Serum TxB2 was measured before and after 5-7 days 100 mg ASA 100 administration. Mean value of serum TxB2 level before and after taking ASA was 16.43 ± 16.08 ng/mL and 2.93 ± 1.83 ng/mL in diabetic and 27.36 ± 21.04 ng/mL and 5.36 ± 4.06 ng/mL in non-diabetic group. Mean reduction of serum TxB2 level in diabetic and non-diabetic group was 13.49 ± 15.9 ng/mL and 22.00 ± 21.65 ng/mL. There were significant differences in serum TxB2 level after taking ASA 100 mg in diabetic and non-diabetic group but the mean reduction of serum TxB2 level were not significantly different.
Korelasi Kadar HMGB1 dalam Serum dengan Derajat Fungsional Neurologik yang Diukur dengan NIHSS pada Pasien Stroke Trombotik Akut Aris Widayati; Mohammad Saiful Islam
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.871 KB) | DOI: 10.20473/aksona.v1i1.103

Abstract

Pendahuluan: High mobility group box 1 (HMGB1), akhir-akhir ini diketahui sebagai salah satu mediator yang memicu proses inflamasi setelah terjadi iskemia di otak. Saat ini telah dikenal beberapa reseptor HMGB1 yang memerantarai proses inflamasi diotak yaitu RAGE, TLR2 dan TLR4. Ikatan HMGB1 dengan reseptornya akan menyebabkan kerusakan neuron otak yang memberikan konstribusi perburukan defisit neurologi klinis. Beberapa studi menunjukkan bahwa kadar HMGB1 meningkat secara signifikan pada pasien stroke dibandingkan kelompok kontrol. Studi lain menunjukkan bahwa kadar HMGB1 yang tinggi setelah iskemia otak akan memperluas area infark. Tujuan: untuk mengetahui adanya korelasi antara kadar HMBG1 dalam serum dengan derajat fungsional neurologik yang diukur dengan NIHSS pada pasien stroke trombotik akut. Metode: Telah diukur kadar HMGB1 pada 43 pasien stroke trombotik akut yang di rawat di ruang saraf RSUD Dr. Soetomo Surabaya periode September 2012 sampai Januari 2013 diukur kadar HMGB1 dengan metode ELISA - Sandwich menggunakan Indirect Capture Re Capture dan diukur derajat fungsional neurologik dengan NIHSS. Hasil: Rerata usia subyek penelitian ini 60.40 ± 9.346 tahun. Subyek penelitian terdiri dari 24 wanita dan 19 pria. Rerata kadar HMGB1 serum adalah 62.57± 54.164 ng/ml. Rerata nilai NIHSS adalah 6.47 ± 3.261. Terdapat korelasi positif dengan kekuatan lemah antara kadar HMGB1 serum dengan nilai NIHSS pada pasien stroke trombotik akut yang bermakna secara statistik (r = 0.353 dan p = 0.02) Kesimpulan: Terdapat korelasi positif antara kadar HMGB1 dalam serum dengan derajat fungsional neurologik yang diukur
Co-Authors Aris Widayati Didik Hasmono Nur Hadiyanti