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All Journal Molekul: Jurnal Ilmiah Kimia Kaunia: Integration and Interconnection of Islam and Science Journal
Susy Yunita Prabawati
Program Studi Kimia, Fakultas Sains dan Teknologi UIN Sunan Kalijaga Yogyakarta
Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Mathematics Physics

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SINTESIS SENYAWA 1,4-BIS [(2-HIDROKSI-3-METOKSI-5- FORMALDEHID-FENIL)-METIL] PIPERAZIN DARI BAHAN DASAR VANILIN DAN UJI AKTIVITASNYA SEBAGAI ZAT ANTIOKSIDAN Susy Yunita Prabawati; Andika Fajar Setiawan; Arini Fawzia Agustina
Kaunia: Integration and Interconnection Islam and Science Vol. 8 No. 1 (2012)
Publisher : Fakultas Sains dan Teknologi UIN Sunan Kalijaga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/kaunia.1039

Abstract

A study has been conducted to synthesize 1,4-bis [(2-hydroxy-3-methoxy-5-methanal- phenyl)-methyl] piperazin using vanillin as a starting material. It was of interest to investigate the activity of that compound, as an antioxidant with DPPH method. The synthesis was carried out through Mannich reaction using vanillin, formaldehida, and piperazin. The product was obtained as a white solid, melting point 245-2470C with a yield of 67.49%.Characterization of the product by IR and 1H  NMR  spectrophotometry, showed the formation of methylene bridge. This indicated that  the compounds synthesized was 1,4-bis [(2-hydroxy-3-methoxy-5-methanal-phenyl)-methyl] piperazin. The test of antioxidant activity with DPPH method showed  that  1,4-bis  [(2-hydroxy-3-methoxy-5-methanal- phenyl)-methyl] piperazin had antioxidant activity better than vanillin with IC50 values was 0.661 mM while vanillin was 3.158 mM.
SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS Susy Yunita Prabawati
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.366 KB) | DOI: 10.20884/1.jm.2016.11.2.244

Abstract

A study has been conducted to synthesize 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin using phenol derivate and investigate the capability of that compound, as an antioxidant. The synthesis was carried out through Mannich reaction using p-t-butylphenol, paraformaldehyde, and piperazine. The product was characterized by IR and 1H NMR spectroscopic. Testing of antioxidant activity was done with the immersion of DPPH (1,1-diphenyl-2 picrylhydrazyl) free radical method. The product was obtained as a white solid, with a point of 252,7-254,7 ºC and a yield of 65.76%. The test of antioxidant activity with DPPH method showed that 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin had the IC50 values was 0.84 nM. It means that the 1,4- bis[(1-hydroxy-4-t-butyl-phenyl )methyl]piperazine has potential as antioxidants.
Co-Authors Andika Fajar Setiawan Arini Fawzia Agustina