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All Journal International Journal of Nursing and Health Services (IJNHS) Jaringan Laboratorium Medis
Putri Wulandari
Poltekkes Kemenkes Semarang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health Social Sciences

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Utilization Alkaline Water as An Alternative Complementary Therapy on Triglyceride Levels among Patients with Grade I Hypertension Putri Wulandari; Ari Suwondo; Rr. Sri Endang Puji Astuti
International Journal of Nursing and Health Services (IJNHS) Vol. 3 No. 6 (2020): International Journal of Nursing and Health Services (IJNHS)
Publisher : Alta Dharma Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35654/ijnhs.v3i6.358

Abstract

Cardiovascular disease a non-communicable disease with a high incidence in Indonesia. Non-communicable diseases are increasing every year, especially in Indonesia. An alternative treatment for hypertension with complementary therapy is alkaline water, which can improve triglyceride levels. This study aimed to examine alkaline water's effect as an alternative, complementary medicine on triglyceride levels among patients with hypertension grade I. This research quasi-experimental with a design using pre-test-test and post-test control group design. Data collection involved 40 respondents of phase I hypertension patients, selected through non-probability sampling with a purposive sampling method divided into two groups. The intervention group received therapy, captopril drug, and simvastatin, with the consumption of alkaline water 8.5 doses 1.5 liters per day for 21 days. In contrast, the control group was only assigned medication according to the doctor's prescription and mineral water consumption with normal power of hydrogen (pH). Independent t-test results showed significant differences with the average triglyceride levels p-value 0.000 (<0.05). The intervention group is better at lowering triglyceride levels than the control group seen from the higher difference values. Conclusion in utilizing alkaline water with a pH of 8.5 doses 1.5 liters per day for 21 days effectively reduces triglyceride levels in grade I hypertension patients
Karakteristik Antibodi Ireguler pada Pasien Gagal Ginjal Kronik di Laboratorium Rujukan UDD PMI Kota Semarang Iin Desmiany Duri; Hilari Rio Rosa; S.Y Didik Widiyanto; Putri Wulandari; Mutia Syafira; Rina Puspita
Jaringan Laboratorium Medis Vol 8 No 2 (2026): November 2026
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v8i2.15541

Abstract

Patients with Chronic Kidney Disease (CKD) undergoing maintenance hemodialysis are highly susceptible to severe anemia and frequently require repeated long-term blood transfusions. This therapeutic intervention exposes patients to non-ABO foreign red blood cell antigens, potentially triggering alloimmunization through the formation of irregular antibodies. These antibodies may compromise transfusion safety and complicate compatibility testing (crossmatching) in transfusion laboratories. This study aimed to determine the prevalence and specificity of irregular antibodies among CKD patients at the Referral Laboratory of the Blood Donor Unit, Indonesian Red Cross (PMI) Semarang City. This descriptive quantitative study analyzed secondary laboratory records from 55 CKD patients collected between July 2020 and September 2025. Immunohematological data included ABO and Rh blood grouping, antibody screening using the Indirect Antiglobulin Test (IAT), Direct Antiglobulin Test (DAT), and antibody identification using a 10-cell red blood cell panel. The results showed that most participants were aged 40–60 years (50.9%), with blood group O being the most prevalent (36.4%). Of the total samples, 17 patients (30.9%) tested positive for irregular antibody screening. Further antibody identification detected Anti-M (MNS blood group system) in two cases (11.8%) and Anti-e (Rh blood group system) in two cases (11.8%). The majority of positive cases (13 patients; 76.4%) demonstrated non-specific antibody reactions. Most non-specific results are thought to be associated with the potential presence of autoantibodies, particularly in patients with a positive Direct Antiglobulin Test (DAT). Patients with chronic kidney disease (CKD) face a relatively high risk of developing irregular antibodies. This condition creates a masking effect that conceals other alloantibodies and leads to major incompatibility during crossmatching. Therefore, it is recommended that reference laboratories routinely employ adsorption techniques to ensure the safety of blood for transfusion.
Co-Authors Ari Suwondo Hilari Rio Rosa Iin Desmiany Duri Mutia Syafira Rina Puspita Rr. Sri Endang Puji Astuti S.Y Didik Widiyanto