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All Journal Indonesian Journal of Urology Hang Tuah Medical Journal
Heru Nurdianto
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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COMPARATIVE EFFICACY OF INTERMITTENT AND DAILY DOXAZOSIN THERAPY FOR LUTS ASSOCIATED WITH BPH Nurdianto, Heru; Alif, Sabilal; Tarmono, Tarmono
Indonesian Journal of Urology Vol 18 No 1 (2011)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v18i1.66

Abstract

Objective: To investigate the efficacy of intermittent doxazosin therapy on LUTS associated BPH. Material  & Method: This study was performed between January to April 2010 enrolling 20 patients with LUTS associated BPH. Study subjects were randomly allocated to 2 therapeutic groups. The first group was assigned daily doxazosin therapy (11 patients), while the second group was assigned intermittent doxazosin therapy (9 patients). Initially all subjects were given doxazosin 2 mg daily for 2 weeks. Subsequently group I received doxazosin 2 mg daily therapy, while group II received doxazosin 2 mg every other day. All medications were taken up to 12 weeks. Outcomes were evaluated prior to therapy, and after 2, 4, 8, and 12 weeks of therapy. Efficacy of doxazosin therapy was measured by International Prostate Symptom Score (IPSS), peak urinary flow rate (Q max), and residual urine volume. Statistical analysis was performed to evaluate difference in efficacy between the treatment groups. Results: Daily doxazosin therapy for 2 weeks resulted in significant improvement of Q max and IPSS. After 4, 8, and 12 weeks significant improvement was maintained in both daily and intermittent groups, as measured by Q max, residual urine volume and IPSS. There were no significant differences in Q max, residual urine volume, and IPSS between the daily and intermittent groups at 4, 8, and 12 groups. Conclusion: There were significant improvements of Q max, residual urine and IPSS at 2 to 12 weeks in daily as well as intermittent doxazosin therapy groups. There were no significant differences in efficacy between daily and intermittent therapy groups
Pengaruh Pemberian Ekstrak Spirulina platensis Terhadap Penurunan Kadar Serum SGPT Tikus Putih Jantan Galur Wistar yang Diinduksi Parasetamol Dosis Tinggi E.J.T, SIHNING; SAES, JOVITASARI ELVIANA PUTRI; ADIWINOTO, RONALD PRATAMA; NURDIANTO, HERU
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.376

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Latar Belakang : Hepatotoksisitas akibat obat merupakan cedera hati yang dapat dipicu karena penggunaan parasetamol dosis tinggi. Metabolisme parasetamol menghasilkan metabolit reaktif NAPQI yang menciptakan kondisi stres oksidatif di hati. Spirulina platensis mengandung fikosianin yang berperan sebagai antioksidan sehingga mampu mengurangi pembentukan radikal bebas. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak Spirulina platensis terhadap penurunan kadar SGPT tikus putih jantan galur Wistar yang diinduksi parasetamol dosis tinggi. Metode : Studi laboratorium eksperimental dengan desain post test only control group pada total 24 tikus yang dibagi kedalam 3 kelompok: (1) Kelompok K(-) diberi makanan standar selama 10 hari; (2) Kelompok K(+) diberi parasetamol dosis 1250mg/kgBB di hari kedelapan; (3) Kelompok perlakuan diberi ekstrak Spirulina platensis dosis 360mg/kgBB selama 10 hari serta diberi parasetamol dosis 1250mg/kgBB di hari kedelapan. Di hari kesepuluh ketiga kelompok diterminasi dan diambil sampel darah untuk pengukuran SGPT. Hasil Penelitian : Rerata SGPT pada kelompok K(-) 58,5 m/l, kelompok K(+) 84,8 m/l, dan kelompok perlakuan 70,7 m/l. Didapatkan perbedaan rerata kadar SGPT kelompok K(+) dan kelompok perlakuan pada p=0,082. Kesimpulan : Pemberian ekstrak alga hijau biru (Spirulina platensis) sebagai antioksidan dengan dosis 360mg/kgBB/hari selama 10 hari memperbaiki fungsi hepar khususnya dalam menurunkan kadar serum SGPT tikus putih jantan galur Wistar yang diinduksi parasetamol dosis tinggi dengan hasil signifikansi 0,082 (p>0,05). Kata Kunci: Spirulina platensis, Antioksidan, Serum glutamate pyruvate transaminase (SGPT), Rattus norvegicus
Co-Authors E.J.T, SIHNING Ronald Pratama Adiwinoto Sabilal Alif SAES, JOVITASARI ELVIANA PUTRI Tarmono Djojodimedjo