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All Journal Jurnal Kedokteran Diponegoro Universa Medicina Paediatrica Indonesiana Belitung Nursing Journal
Santoso Santoso
Department Of Biochemistry, Faculty Of Medicine, Diponegoro University, Semarang
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Paediatrica Indonesiana

 1 
Effect of carnitine in diphtheria: A preliminary report Soetono Soetono; Santoso Soeroso; Warsito Sutikno
Paediatrica Indonesiana Vol 39 No 3-4 (1999): March - April 1999
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2074.456 KB) | DOI: 10.14238/pi39.3-4.1999.102-7

Abstract

A double placebo controlled trial was conducted on 68 diphtheriapatients who were hospitalized in pediatric ward of Kariadi Hospital, Semarang, from 1 April 1990 to 31 March 1991. The age range of the patients was between 7 months to 13 years, with the median of 48 months and the mean of 60.5 (SD 11) months. The pretreatmentcharacteristics of both groups were similar with respect to sex, the clinical condition on admission, presence of bullneck, nutritional and immunization status. Oral camitine was administered with a dose of 100 mg/kg/ day divided into 3 doses. Other standard treatment was administered to all patients. Post-treatment comparisons were performed on the prevalence of myocarditis, CK-MB level examined on the fifth day of treatment, and mortality. It was found that the prevalence of myocarditis and CK-MB levels' were significantly less than those in the placebo group, while the mortality in the carnitine group (3%) although smaller than in placebo group (17%) was not statistically different. It seems that 1-camitine is useful to prevent diphtheritic myocarditis,while its effect on improving the overall prognosis needs further study.
Neurological Sequalae in Survivors of Perinatal Asphyxia Tjipta Bahtera; Santoso Suroso; Bambang Darmanto
Paediatrica Indonesiana Vol 32 No 7-8 (1992): July - August 1992
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.108 KB) | DOI: 10.14238/pi32.7-8.1992.169-77

Abstract

Perinatal asphyxia is the most common cause of either death or severely handicapped survivors. Perinatal asphyxia can be identified by one, five, ten minutes APGAR scores less than 7. Prolonged asphyxia produce hypoxemia, acidosis, hypercapnia, thus diminishing cerebral blood flow, which in turn results in clinical patterns of Hypoxic - Ischemic Encephalopathy (HIE). The atm of this study was to evaluate the accuracy of clinical observation on newborn asphyxia to predict the presence of neurological deficits connected with blood gas analysts investigation. Thirty eight newborn babies who bad APGAR scores of less than 7 as an asphyctic newborn baby group compared with an equal number of normal babies as control group. Physical and neurological examinations were performed immediately after birth and at six months of age. Two of the 38 infants who bad perinatal asphyxia died several hours after birth. Two of the 31 of the surviving infants with a historical of perinatal asphyxia bad cerebral palsy. One of the two babies with cerebral palsy bad epilepsy. Twenty nine of the 31 of the surviving infants with a history of perinatal asphyxia with or without mild HIE showed normal neurological outcomes. All of the normal newborn babies as control showed normal neurological outcome. One infant with cerebral palsy and one infant who bad cerebral palsy with epilepsy bad a history of a severe degree of HIE and moderate degree of Hm with neonatal convulsion respectively. One of the 2 infants with cerebral palsy bad severe hypoxia and none on the infants with normal neurological outcome exhibited Pa02 less than 50 mmHg. There were no significant differences ( p > 0.05) of the Pa02 PH and base deficit between the infants with a history of asphyxia and with a history of a vigorous baby, who bad a normal outcome. We concluded that postasphyxia encephalopathy was more accurate than a low APGAR score in predicting an adverse outcome, and the value of the Pa02 very important in predicting an encephalopathy.
Co-Authors - Anggorowati Bambang Darmanto Djuara P Lubis Kusmiyati Tjahjono Kusmiyati Tjahjono DK Muhammad Iqbal Reynaldi Rita Kartika Sari Soetono Soetono Tjipta Bahtera Warsito Sutikno