This study aims to determine the Comparison of the Effectiveness of Brain Gym and Puzzle Playing Against the Development of Fine Motorcycles in Preschoolers in the Work Area of ​​the Basuki Rahmad Community Health Center in Bengkulu City. Quantitative research design using the Quasy Experiment design, two groups of pre-post tests equivalent without control design. The results of univariate analysis with brain gym intervention, from 15 respondents before the brain gym there were 9 children (60%) experienced deviant fine motor skills and after given 11 children therapy (73.3%) experienced normal fine motor skills. Whereas from the 15 respondents before intervening tubuzzle, there were 8 children (53.3%) having deviated fine motor skills and after being given a puzzle 15 respondents (100%) experienced normal fine motor skills. The bivariate results of Wilcoxon test have the effect of brain gym with p-value = 0,000 and puzzle with p-value = 0.001 in the development of fine motor in preschool children. Mann Whitney test results obtained p-value = 0.005. Conclusion, playing puzzles was more effective in the development of fine motor skills of preschoolers in the Basuki Rahmad Community Health Center in the City of Bengkulu. Keywords: Brain gym, Motor, Preschool, Puzzle