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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Natural Sciences Engineering and Technology Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research
Alwi Shahab
Department Of Internal Medicine, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Aerospace Engineering Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Energy Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Social Sciences Transportation

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Sepsis-Induced Diabetic Ketoacidosis (DKA) in Latent Autoimmune Diabetes in Adult (LADA) Fadel Fikri Suharto; Alwi Shahab; Yulianto Kusnadi; RM Dewi Anggraini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 2 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i2.452

Abstract

Backgrounds. Latent autoimmune diabetes in adults (LADA) is a slowly progressive form of autoimmune diabetes mellitus characterized by older age at diagnosis, presence of pancreatic autoantibodies, and lack of absolute insulin requirement at diagnosis. Patients with LADA had better β-cell function than patients with classic Type 1 DM (T1DM). Overtime, LADA tends to experience rapid and progressive loss of beta cell function that requires intensive insulin therapy. This case report aims to describe a case of Diabetic Ketoacidosis (DKA) in a patient with latent autoimmune diabetes in adult (LADA) induced by sepsis (urinary tract infection/UTI). Case Presentations. A woman, 28 years-old, came to the Emergency Department (ED) RSMH Palembang with chief complaints of decreased consciousness and shortness of breath. Patient had a history of frequent urination, pain when urinating, and fever. Urinalysis examination were glycosuria, proteinuria, hematuria. Hb-A1c level was 10.7%, C-Peptide 0.11 ng/dL, Anti GAD65 qualitative positive, and Islet cell antibody (ICA) negative. Patient was diagnosed with diabetic ketoacidosis (DKA), LADA, and sepsis due to urinary tract infection (UTI). Patients were managed with DKA and sepsis management algorithm. Conclusion. Diabetic ketoacidosis (DKA) in LADA caused by sepsis is an emergency in the metabolic endocrine and diabetes fields. Prompt and appropriate management can improve outcome prognosis in this case.
Sepsis-Induced Diabetic Ketoacidosis (DKA) in Latent Autoimmune Diabetes in Adult (LADA) Fadel Fikri Suharto; Alwi Shahab; Yulianto Kusnadi; RM Dewi Anggraini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 2 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i2.452

Abstract

Backgrounds. Latent autoimmune diabetes in adults (LADA) is a slowly progressive form of autoimmune diabetes mellitus characterized by older age at diagnosis, presence of pancreatic autoantibodies, and lack of absolute insulin requirement at diagnosis. Patients with LADA had better β-cell function than patients with classic Type 1 DM (T1DM). Overtime, LADA tends to experience rapid and progressive loss of beta cell function that requires intensive insulin therapy. This case report aims to describe a case of Diabetic Ketoacidosis (DKA) in a patient with latent autoimmune diabetes in adult (LADA) induced by sepsis (urinary tract infection/UTI). Case Presentations. A woman, 28 years-old, came to the Emergency Department (ED) RSMH Palembang with chief complaints of decreased consciousness and shortness of breath. Patient had a history of frequent urination, pain when urinating, and fever. Urinalysis examination were glycosuria, proteinuria, hematuria. Hb-A1c level was 10.7%, C-Peptide 0.11 ng/dL, Anti GAD65 qualitative positive, and Islet cell antibody (ICA) negative. Patient was diagnosed with diabetic ketoacidosis (DKA), LADA, and sepsis due to urinary tract infection (UTI). Patients were managed with DKA and sepsis management algorithm. Conclusion. Diabetic ketoacidosis (DKA) in LADA caused by sepsis is an emergency in the metabolic endocrine and diabetes fields. Prompt and appropriate management can improve outcome prognosis in this case.
Association between Body Mass Index, Waist Circumference and Gastroesophageal Reflux Disease Questionnaire Scores: A Cross-Sectional Study Aurel Feodora Tantoro; Alwi Shahab; Syarif Husin; Ratna Maila Dewi Anggraini; Liniyanti D. Oswari
Natural Sciences Engineering and Technology Journal Vol. 2 No. 1 (2022): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v2i1.14

Abstract

The prevalence of gastroesophageal reflux disease (GERD) has continued to increase in Asian countries in recent decades. Many studies have revealed that obesity in general or abdominal obesity causes a significant increase in the risk of GERD symptoms. This study aimed to determine the relationship between body mass index (BMI) and waist circumference with the incidence of GERD in the adult population of Palembang city. This study was observational research with a cross-sectional design. The population was all adults (≥20 years) of Palembang. The number of samples was 400 people. Data were taken from a self-completed questionnaire, distributed through social media, then analyzed using logistic regression analysis. Among 400 subjects in the study, there were 81 subjects (20.3%) diagnosed with GERD, 43 subjects (10.8%) were overweight, 79 subjects (19.8%) were obese, and 160 subjects(40%) had abdominal obesity. There was a significant relationship between obesity and diagnosis of GERD (p=0,001; OR =2,799; CI 95% = 1,545-5,069). In contrast, there was no significant relationship between being overweight and diagnosis of GERD. There was also no significant relationship between abdominal obesity and diagnosis of GERD. Obesity has a significant association with the diagnosis of GERD, but the absence of an association between overweight and diagnosis of GERD implies that increased BMI is not an independent risk factor in diagnosis of GERD.
Co-Authors Aurel Feodora Tantoro Fadel Fikri Suharto Muhammad Irsan Saleh Oswari, Liniyanti D Ratna Maila Dewi Anggraini RM Dewi Anggraini Rostika Dewi Syarif Husin Yulianto kusnadi Zulkhair Ali