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The Role of Calcium in the Skin Barrier Nopriyati; Ahmad Ligar Suherman; Yulia Farida Yahya; Mutia Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.543

Calcium is a macro mineral that is an important part of the body. Bones and teeth contain more than 99% of the human body calcium. Calcium also found in other tissues such as skin. The concentration of calcium in the body tends to decrease with age because released from the body through sweat, skin cells, and faeces. Calcium intake varies worldwide with an average of 175-1233 mg/day. Many countries in Asia have an average calcium intake of less than 500 mg/day. The skin barrier function is in the epidermis, the formation of the epidermal barrier and the maintenance of homeostasis are important to protect the individual from the external environment and organisms. Epidermal calcium gradient, endoplasmic reticulum (ER) calcium homeostasis, and calcium influx through calcium channels play important roles in keratinocyte differentiation, barrier formation, and barrier homeostasis. Understanding the mechanism of regulation and function of calcium related to skin barrier homeostasis is aimed to improve understanding of calcium in the skin barrier

The Role of Calcium in the Skin Barrier Nopriyati; Ahmad Ligar Suherman; Yulia Farida Yahya; Mutia Devi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.543

Calcium is a macro mineral that is an important part of the body. Bones and teeth contain more than 99% of the human body calcium. Calcium also found in other tissues such as skin. The concentration of calcium in the body tends to decrease with age because released from the body through sweat, skin cells, and faeces. Calcium intake varies worldwide with an average of 175-1233 mg/day. Many countries in Asia have an average calcium intake of less than 500 mg/day. The skin barrier function is in the epidermis, the formation of the epidermal barrier and the maintenance of homeostasis are important to protect the individual from the external environment and organisms. Epidermal calcium gradient, endoplasmic reticulum (ER) calcium homeostasis, and calcium influx through calcium channels play important roles in keratinocyte differentiation, barrier formation, and barrier homeostasis. Understanding the mechanism of regulation and function of calcium related to skin barrier homeostasis is aimed to improve understanding of calcium in the skin barrier

Secukinumab Therapy on Psoriasis at Dr. Mohammad Hoesin General Hospital Palembang Nopriyati; Rio Tampubolon; Sarah Diba; M Athuf Thaha; Theresia L Toruan; Fitriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.612

Background: Psoriasis is a chronic inflammatory skin disease mediated by T lymphocytes. IL-17 or IL-22 plays an important role in the chronic inflammatory process. Secukinumab is an effective biological agent therapy with a molecular target, IL-17A. This study aimed to describe PASI improvement and safety of using secukinumab in psoriasis patients at the Dermatology and Venereology Clinic Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study was a retrospective, descriptive-analytic study. The inclusion criteria of this study were all medical record data of patients diagnosed with cutaneous psoriasis through anamnesis, clinical and histopathology examination, treated with secukinumab from January 2018 to December 2020. Results: Psoriasis patients with secukinumab therapy were 15 people. The number of male patients was 8 people, the mean age (+ SD) was 40.4, + 12.34 years, and the age range was 19-64 years. A family history of psoriasis was present in 2 patients (13.4%). Psoriasis vulgaris was the most prevalent type of psoriasis and was treated with secukinumab in 8 patients (53.3%). Another type was pustular psoriasis (20%) and erythrodermic psoriasis (26,7%). The triggers of exacerbations obtained in this study include occupation, hypertension, diabetes mellitus, obesity, smoking, and infections. PASI 75 was achieved by 13 patients (86.7%) at week 12, and all patients achieved DLQI<5. There were no adverse events during the use of secukinumab. Conclusion: The improvement of PASI and DLQI scores were achieved at week 12 in accordance with previous studies. Risk factors do not reduce the therapeutic effect of secukinumab in achieving PASI 75.

Application of Topical Autologous Platelet-Rich Plasma for Treatment of Pemphigus Foliaceus Wounds: A Case Report Nopriyati; M. Akip Riyan Saputra; Yulia Farida Yahya; Sarah Diba
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.625

Background: Pemphigus foliaceus (PF) includes lesions on the skin, generally without involving the mucosa. Wounds in PF arise on the outer layer of the superficial skin, but if left untreated, the wound will not heal and will multiply. Platelet-rich plasma (PRP) containing a variety of different growth factors can be used in wound care. This study was at a time to describe autologous PRP therapy in the treatment of excoriated erosional wounds in patients with pemphigus foliaceus. Case presentation: A woman, 35 years old, married, a housewife living in suburban, comes to the emergency department with complaints of blisters accompanied by pain in the face, body, and back which has been increasing since 1 month ago. Examination of the skin showed palpebral blisters on the eyelids of the left and right eyes. In the anterior and posterior trunk regions, proximal 1/3rd and suprapubic extremities, there are hyperpigmented erythematous macules, multiple, nummular-plaque, discrete, partially confluent, with white to brownish scales, single layer and exfoliative. In the posterior trunk region, Nikolsky's sign was positive. Laboratory evaluation showed an increase in leukocytes and neutrophils. ANA examination showed negative results and anti-ds-DNA 54.91. Management of pemphigus in the form of topical and systemic treatment. Topical management in the form of an open compress with 0.9% NaCl solution, Intrasite gel®, and closed Cutimed sorbact® for erosion and excoriation. Topical PRP was administered on the 7th day of treatment. On the 14th day after treatment with topical PRP, the patient is allowed to go home with the repair of lesions throughout the region. Conclusion: PRP therapy in cases of pemphigus foliaceus is very useful in improving the clinical condition of the patient.

The Role of Topical Vitamin D in Vitiligo: A Narrative Literature Review Nopriyati; M. Akip Riyan Saputra; Izazi Hari Purwoko; Theresia L. Toruan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.626

Vitamin D plays a role in the process of melanogenesis, namely increasing L-Dopa cells, inducing differentiation of immature melanocytes, and increasing melanocyte activity. The use of vitamin D in dermatology is in the treatment of vitiligo, psoriasis vulgaris, atopic dermatitis, verruca vulgaris, and alopecia. Vitiligo is an autoimmune disease of the skin in the form of depigmentation due to the destruction of melanocytes by T cells. The clinical manifestations of vitiligo are white macular lesions and no scale, asymptomatic, and symmetrical. Vitiligo can affect the patient's quality of life, so accurate therapy is needed. Standard therapy in vitiligo needs further research to find accurate therapy with minimal side effects. Topical vitamin D is a vitiligo therapy with minimal side effects. Several types of topical vitamin D with therapeutic effects in the field of dermatology are calcipotriol, calcitriol, tacalcitol, maxacalcitol, and hexafluoro-1,25 dihydroxyvitamin D3 with various dosages and preparations. The role of vitamin D in melanogenesis and immunomodulators as monotherapy or in combination with topical corticosteroids has been shown to be effective in the treatment of vitiligo. This literature review was on the role of topical vitamin D in the treatment of vitiligo.

Extensive Actinomycetoma Clinical Manifestations and Histopathology: A Case Report Fifa Argentina; Rusmawardiana; Nopriyati; Putri Laksmi Karim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.671

Background: Actinomycetoma is a chronic infection of cutis, subcutaneous, bone, and viscera tissue. It is characterized by sinuses containing masses of causative organisms often referred to as "grains." Actinomycetoma is caused by aerobic bacteria, and they have been misclassified as a fungal species. Diagnosis of actinomycetoma was based on clinical features and confirmation by direct examination. This study aimed to describe the clinical and histopathological features of actinomycetoma. Case presentation: A 34-year-old woman complained of a mass on her left leg that had increased in number and pain 3 months before admission to the hospital with a history of trauma. Regio pedis sinistra has trias mycetoma, such as edema (swelling), multiple sinuses, and grain with hypertrophic scars. Histopathological with fibro collagenous connective tissue, moderate to dense diffuse PMN inflammatory cells, plasma cells, lymphocytes, hemosiderophages, multinucleated giant cells, epithelioid cells, and microorganisms. In periodic acid Schiff (PAS) there is the Splendore-Hoeppli phenomenon. Conclusion: Diagnosis of actynomycetoma was confirmed by the mycetoma triad and the Splendore-Hoeppli phenomenon. Actinomycetoma is more invasive and can cause bone destruction more quickly than eumycetoma.

Secukinumab Therapy on Psoriasis at Dr. Mohammad Hoesin General Hospital Palembang Nopriyati; Rio Tampubolon; Sarah Diba; M Athuf Thaha; Theresia L Toruan; Fitriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.612

Background: Psoriasis is a chronic inflammatory skin disease mediated by T lymphocytes. IL-17 or IL-22 plays an important role in the chronic inflammatory process. Secukinumab is an effective biological agent therapy with a molecular target, IL-17A. This study aimed to describe PASI improvement and safety of using secukinumab in psoriasis patients at the Dermatology and Venereology Clinic Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study was a retrospective, descriptive-analytic study. The inclusion criteria of this study were all medical record data of patients diagnosed with cutaneous psoriasis through anamnesis, clinical and histopathology examination, treated with secukinumab from January 2018 to December 2020. Results: Psoriasis patients with secukinumab therapy were 15 people. The number of male patients was 8 people, the mean age (+ SD) was 40.4, + 12.34 years, and the age range was 19-64 years. A family history of psoriasis was present in 2 patients (13.4%). Psoriasis vulgaris was the most prevalent type of psoriasis and was treated with secukinumab in 8 patients (53.3%). Another type was pustular psoriasis (20%) and erythrodermic psoriasis (26,7%). The triggers of exacerbations obtained in this study include occupation, hypertension, diabetes mellitus, obesity, smoking, and infections. PASI 75 was achieved by 13 patients (86.7%) at week 12, and all patients achieved DLQI<5. There were no adverse events during the use of secukinumab. Conclusion: The improvement of PASI and DLQI scores were achieved at week 12 in accordance with previous studies. Risk factors do not reduce the therapeutic effect of secukinumab in achieving PASI 75.

Application of Topical Autologous Platelet-Rich Plasma for Treatment of Pemphigus Foliaceus Wounds: A Case Report Nopriyati; M. Akip Riyan Saputra; Yulia Farida Yahya; Sarah Diba
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.625

Background: Pemphigus foliaceus (PF) includes lesions on the skin, generally without involving the mucosa. Wounds in PF arise on the outer layer of the superficial skin, but if left untreated, the wound will not heal and will multiply. Platelet-rich plasma (PRP) containing a variety of different growth factors can be used in wound care. This study was at a time to describe autologous PRP therapy in the treatment of excoriated erosional wounds in patients with pemphigus foliaceus. Case presentation: A woman, 35 years old, married, a housewife living in suburban, comes to the emergency department with complaints of blisters accompanied by pain in the face, body, and back which has been increasing since 1 month ago. Examination of the skin showed palpebral blisters on the eyelids of the left and right eyes. In the anterior and posterior trunk regions, proximal 1/3rd and suprapubic extremities, there are hyperpigmented erythematous macules, multiple, nummular-plaque, discrete, partially confluent, with white to brownish scales, single layer and exfoliative. In the posterior trunk region, Nikolsky's sign was positive. Laboratory evaluation showed an increase in leukocytes and neutrophils. ANA examination showed negative results and anti-ds-DNA 54.91. Management of pemphigus in the form of topical and systemic treatment. Topical management in the form of an open compress with 0.9% NaCl solution, Intrasite gel®, and closed Cutimed sorbact® for erosion and excoriation. Topical PRP was administered on the 7th day of treatment. On the 14th day after treatment with topical PRP, the patient is allowed to go home with the repair of lesions throughout the region. Conclusion: PRP therapy in cases of pemphigus foliaceus is very useful in improving the clinical condition of the patient.

The Role of Topical Vitamin D in Vitiligo: A Narrative Literature Review Nopriyati; M. Akip Riyan Saputra; Izazi Hari Purwoko; Theresia L. Toruan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.626

Vitamin D plays a role in the process of melanogenesis, namely increasing L-Dopa cells, inducing differentiation of immature melanocytes, and increasing melanocyte activity. The use of vitamin D in dermatology is in the treatment of vitiligo, psoriasis vulgaris, atopic dermatitis, verruca vulgaris, and alopecia. Vitiligo is an autoimmune disease of the skin in the form of depigmentation due to the destruction of melanocytes by T cells. The clinical manifestations of vitiligo are white macular lesions and no scale, asymptomatic, and symmetrical. Vitiligo can affect the patient's quality of life, so accurate therapy is needed. Standard therapy in vitiligo needs further research to find accurate therapy with minimal side effects. Topical vitamin D is a vitiligo therapy with minimal side effects. Several types of topical vitamin D with therapeutic effects in the field of dermatology are calcipotriol, calcitriol, tacalcitol, maxacalcitol, and hexafluoro-1,25 dihydroxyvitamin D3 with various dosages and preparations. The role of vitamin D in melanogenesis and immunomodulators as monotherapy or in combination with topical corticosteroids has been shown to be effective in the treatment of vitiligo. This literature review was on the role of topical vitamin D in the treatment of vitiligo.

Extensive Actinomycetoma Clinical Manifestations and Histopathology: A Case Report Fifa Argentina; Rusmawardiana; Nopriyati; Putri Laksmi Karim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.671

Background: Actinomycetoma is a chronic infection of cutis, subcutaneous, bone, and viscera tissue. It is characterized by sinuses containing masses of causative organisms often referred to as "grains." Actinomycetoma is caused by aerobic bacteria, and they have been misclassified as a fungal species. Diagnosis of actinomycetoma was based on clinical features and confirmation by direct examination. This study aimed to describe the clinical and histopathological features of actinomycetoma. Case presentation: A 34-year-old woman complained of a mass on her left leg that had increased in number and pain 3 months before admission to the hospital with a history of trauma. Regio pedis sinistra has trias mycetoma, such as edema (swelling), multiple sinuses, and grain with hypertrophic scars. Histopathological with fibro collagenous connective tissue, moderate to dense diffuse PMN inflammatory cells, plasma cells, lymphocytes, hemosiderophages, multinucleated giant cells, epithelioid cells, and microorganisms. In periodic acid Schiff (PAS) there is the Splendore-Hoeppli phenomenon. Conclusion: Diagnosis of actynomycetoma was confirmed by the mycetoma triad and the Splendore-Hoeppli phenomenon. Actinomycetoma is more invasive and can cause bone destruction more quickly than eumycetoma.

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