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Florenly
Departement of Medicine, Faculty of Medicine, Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Mathematics Medicine & Pharmacology Physics

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Effects of Curcuma Longa Ethanol Extract on Isolated Guinea Pigthile Smooth Muscle in Acetylcholine Induction Zheng Yuebin; Florenly; Liena; Fioni
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 1 (2022): Britain International of Exact Sciences Journal, January
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i1.540

Abstract

Epidemiological studies show that nearly 20% of the world's population suffers from diseases related to allergies and asthma. The main compound of turmeric is curcumin has several pharmacological properties, antioxidant properties, anti-inflammatory, asthma treatment. The study aimed to determine the effects of ethanol extract Curcuma longa on the smooth muscle of the isolated guinea pigtic trachea in acetylcholine induction. This research method was experimental to observe the relationship of Curcuma longa ethanol extract (EECL) to the relaxing effects of isolated smooth muscle trachea marmot (tracheal ring chain) inserted into a bath organ filled with Kreb's physiological fluid by maintaining a temperature of 35-370C and associated with a Matlab recorder. Samples used by male guinea pigs and ethanol extract Curcuma longa (EECL). The results of the study that ethanol extract Curcuma longa has a relaxing effect on the smooth muscles of the trachea isolated from the experimental rats contracted with acetylcholine. Ethanol extract Curcuma longa has the ability not dising from theophylline 2 x 10-4 M in reducing smooth muscle contraction of insulated Cavia porcelain trachea induced by acetylcholine, acetylcholine strength without incubation contraction compared to acetylcholine with EECL incubation showed statistically different results (p <0.05). The mechanism of Curcuma longa relaxation effect on isolated guinea pig smooth muscle is mediated through inhibition of the enzyme PDE.
Influence before and after Early Mobilization of Changes in Pain Levels in Post Orthopedic Surgery Patients at Royal Prima Medan Hospital in 2021 Zhan Chengwu; Florenly; Johannes Bastira Ginting; Fioni
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 1 (2022): Britain International of Exact Sciences Journal, January
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i1.541

Abstract

Orthopedic surgery is a surgical action associated with the correction of musculoskeletal system deformities and orthopedic problems that aim to improve function by restoring movement and stability and reducing pain and disabilities. Early mobilization is a prominent factor in speeding up postoperative recovery and may prevent postoperative complications. This study aims to find out the influence before and after early mobilization of changes in pain levels in orthopedic postoperative clients at RSU Royal Prima. This type of research uses a correlational descriptive research design, using the One Group Pretest-Postest approach. The location of this study was conducted at RSU Royal Prima Medan in March 2021. The population of all patients’ post-surgery orthopedic hospitalization amounted to 176 patients. The size of the sample uses the formula Structural Equation Modelling (SEM), then the number of samples is determined to be 100 people. Univariate analysis, bivariate with t-dependent test (paired t-test) with a meaningful limit of 0.05. The results of the study that there was a change in the level of pain Wilcoxon test results at the time of the pre-test the result of the mean value of 3.82, at the time of the post-test test the mean value was 2.34. So the result of Z = -5,358 then p-value as much as 0.004 < 0.05 so that Ho is rejected and Ha accepts. The conclusion of the level of pain before early mobilization in the client post orthopedic surgery the majority feels even more pain and the minority experience severe pain. The level of pain after early mobilization in the majority of orthopedic postoperative clients was slightly more painful and the minority felt even more pain. There is an early mobilization effect on pain changes in orthopedic postoperative clients in patients in the hospital room of RSU Royal Prima in 2021.
Analysis of Wound Healing from Andaliman Fruit Essential Oil Ointment (Zanthoxylum Canthopodium Dc.) on Wistar Rats (Rattus Norvegicus) Xu Xuliang; Florenly; Johannes Bastira Ginting; Fioni
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 1 (2022): Britain International of Exact Sciences Journal, January
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i1.542

Abstract

Injuries are cases of injury that are often experienced by every human being. A wound is the loss or damage of some body tissue. Many andaliman fruits contain many phytochemicals such as phenols, saponins, flavonoids, triterpioids, and alkaloids. Its terpenoid content has antioxidant and antimicrobial activity repellents. Iris / incision wounds, which are wounds caused by sharp object slices such as knives, cause damage to vessels that are large enough if the slice is deep enough. This study aims to find out the effect of Andaliman Fruit Essential Oil Saleb (Zanthoxylum acanthopodium DC.) on wound healing in white rats. This experimental study with the approach of Pre-test and Post-test group only control design was conducted January to February 2021, at the Herbarium Medanese FMIPA USU, the Pharmacognosive Laboratory of the Faculty of Pharmacy USU, and the Laboratory of Pharmaceutical Pharmacology USU. The samples were Andaliman Fruit (Zanthoxylum acanthopodium DC.), and male white rats. The number of samples using frederer formula, so determined the number of as many as 25 rats selected randomly divided into 5 groups. Data analysis uses the normality test statistical data test, and the ANOVA test. The results of the study that andaliman fruit extract has several bioactive compounds such as alkaloids, flavonoids, saponins, and tannins that play a role in wound healing. The optimum concentration of Saleb Andaliman fruit essential oil that can heal wounds in white rats is 5%. The highest percentage of cures on the 14th day was in positive control (Bioplacenton®) which was 95% and followed by an extract of 5% v/v with a cure percentage of 90%. Essential oil of andaliman fruit extract has the ability to approach Bioplacenton® in healing wounds in mice.
Co-Authors Johannes Bastira Ginting Liena Liena Xu Xuliang Zhan Chengwu Zheng Yuebin