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All Journal Indonesian Journal of Cardiology
Berlian Idriansyah Idris
Department of Cardiology and Vascular Medicine Faculty of Medicine, University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta
Health Professions Medicine & Pharmacology

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Gap Junctions pada Ischemia-Related Ventrikel Aritmia Berlian Idriansyah Idris; Yoga Yuniadi
Jurnal Kardiologi Indonesia Vol. 32, No. 1 Januari - Maret 2011
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v32i1.123

Abstract

Cardiovascular diseases are the leading cause of death worldwide, with isch-emic heart disease being the most common entity. Ventricular arrhythmia is one of the complications of ischemia that can result in sudden cardiac death. One of the underlying mechanisms of ischemia induced arrhythmia is closure of cardiac myocytes gap junctions, where gap junctions are channel-like structure between cells that allow passage of molecules and electrical current. During ischemia, gap junctions close incompletely, creating tissue impedance heterogeneity and conduction slowing, which provide substrate for ventricular arrhythmia. Conditions where gap junctions structure is altered, such as in heart failure, is associated with increased vulnerability of ischemia-induced ventricular arrhythmia.
Co-Authors Yoga Yuniadi