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All Journal Indonesian Journal of Cardiology Cardiovascular and Cardiometabolic Journal (CCJ)
Febryanti Hartono
Department Of Cardiology And Vascular Medicine, Dr. Ramelan Navy Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Effect of Sweet Purple Potato (Ipomoea batatas L.) Extract and Vitamin C on Endothelial Progenitor Cell Migration in Stable Coronary Disease Patient Febryanti Hartono; Yudi Her Oktaviono; Djoko Soemantri
Jurnal Kardiologi Indonesia Vol 40 No 4 (2019): Indonesian Journal of Cardiology: October-December 2019
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v40i4.843

Abstract

Background: Number and function of Endothelial Progenitor Cells (EPC) are reduced incoronary artery disease (CAD) patient. EPC as progenitor of mature endothelial cell has important role for angiogenesis and neovasculogenesis. Dysfunctional EPC partly because of oxidative stress. Decreasing oxidative stress with antioxidant especially with sweet purple potato extract and vitamin as easily found in Indonesia, may improve EPC migration to ischemic organ in stable CAD patient. Purpose : To analyze effect of sweet purple potato (Ipomoea batatas L.) extract and vitamin C on Endhotelial Progenitor Cell in Stable Coronary Disease patient. Method: This is experimental post-test control group study. Mononuclear cells (MNC) are isolated from peripheral blood of sample, and cultivated in medium for 3 days, immunofluorescence assay with CD34 as a marker for EPC. EPCs divided into sweet purple potato extract group (1 and 25 mcg/mL), vitamin C group (10 and 250 mcg/mL) and control, incubated for 2 days. 5x105 cell taken from each group and place in upper chamber of Transwell system. EPC migration was assessed in lower chamber of Transwell system after 24 hours using automated cell counters. Statistic testing using ANOVA. Results: EPC migration was increased significantly in sweet purple potato extract and vitamin C compared with control (3.03 ± 0.01, 2.15 ± 0.03 vs control 1.21 ± 0.04, p<0.01). Increased dose of sweet purple potato extract and vitamin C shows significantly increased of EPC migration (1.81 ± 0.02 vs1.47 ± 0.04 and 3.03 ± 0.01 vs 2.15 ± 0.03, p<0.01). There is significantly diferentiation between sweet potato purple extract and vitamin C (3.03 ± 0.01 vs 2.15 ± 0.03, p<0.01). Conclusion: Sweet purple potato extract and vitamin C increased EPC migration dose-dependently. Sweet purple potatao extract induces EPC migration better than vitamin C. Keywords: EPC migration, Stable CAD, sweet purple potato extract, vitamin C, antioxidant
Ventricular Septal Rupture (VSR) in Post-Acute Anterior Myocardial Infarction Patients : A Case Series Ken Christian Kawilarang; I Kadek Herry Hermawan; Febryanti Hartono
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 2 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i2.2022.100-111

Abstract

Case Summary: We present 2 cases of post-STEMI VSR. They had anterior AMI without reperfusion therapy because of patient delay and limited resources. Thereafter apical VSR occurs on 5th day. VSR was suspected because of sudden hemodynamic deterioration and new holosystolic murmur (Grade III/VI) at left parasternal line of fourth-fifth ICS. Then it was confirmed by echocardiography. Both patients underwent hemodynamic stabilization while waiting for surgical therapy. Unfortunately, they deceased because of cardiogenic shock accompanied by other comorbidities. Discussion: VSR causes shunt from left to the right ventricle, which overloads the RV, leading to cardiogenic shock. The peak incidence of VSR in the first 24 hours or 3-5 days post-AMI. This fits both of our cases. VSR occurs in total coronary occlusion, which then causes coagulation necrosis in the ischemic area, characterized by neutrophils that trigger apoptosis and lytic enzymes, so that septum becomes thin, brittle then ruptures. VSR is most common in anterior AMI and the defect is at apical septum, as in our patients. Definitive therapy for VSR is surgical closure, but the best timing is still under debate. This article is expected to make us more aware of post-AMI VSR, so we can quickly diagnose and promptly treat the patients with multidisciplinary approach. This is very important to optimize patient’s outcomes even in limited resources area.
Silent Threat: Ascending Aortic Dissection Triggering Congestive Heart Failure in A Young Indonesian Woman Suspected of Marfan Syndrome – A Case Report Shinta Dewi Rasti; Richardus Rukma Juslim; Febryanti Hartono
Cardiovascular and Cardiometabolic Journal (CCJ) Vol. 5 No. 1 (2024): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v5i1.2024.62-71

Abstract

Highlights: 1. Thoracic Aortic Aneurysm is not frequently discussed. However, this study analyzed it and pointed out how life-threatening a disease with silent nature could be. 2. It shows how screening for patient needed to be conducted thoroughly to ensure there is no potential threat left undiagnosed. - Background: A considerable number of thoracic aortic aneurysms (TAAs) remain unidentified or misdiagnosed owing to the silent nature of the disease and the lack of a screening program. The diagnostic process is frequently intricate, leading to potentially catastrophic outcomes. Case presentation: A 32-year-old woman presented with shortness of breath and swelling in both legs, resembling symptoms of heart failure. Despite the absence of known cardiovascular risk factors, echocardiography unveiled a critical condition; painless ascending aortic aneurysm with dissection, posing a life-threatening risk. Conclusion: Initially, the patient's susceptibility to the disease was not readily apparent. Interestingly, aortic dissection patients presenting with heart failure symptoms were less inclined to experience chest pain compared to those without such symptoms. This disparity might triple the time required for diagnosis and elevate mortality risk to 33%. Thus, this case report aims to increase awareness in the medical community about rare and subtle cases that might be overlooked or misdiagnosed due to atypical presentations.
Co-Authors I Kadek Herry Hermawan Ken Christian Kawilarang Richardus Rukma Juslim Shinta Dewi Rasti Soemantri, Djoko Yudi Her Oktaviono, Yudi Her