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All Journal Jambura Journal of Health Sciences and Research Proceedings of Malikussaleh International Conference on Health and Disaster Medicine (MICOHEDMED)
Sahna Ferdinand
Universitas Prima Indonesia, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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EFFECTIVENESS ANTIBACTERIAL OF POWWOOD EXTRACT (SPATHOLOBUS LITTORALIS HASSK) AGAINST PSEUDOMONAS AERUGINOSA Weldy Stephan; Angelia Armita; Qori Fadillah; Sahna Ferdinand
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.12368

Abstract

Bajakah Tampala (Spatholobuslittoralis Hassk) adalah salah satu tanaman yang banyak tumbuh pada Kalimantan Tengah namun belum banyak dimanfaatkan. Kebaruan dalam penelitian ini karena melakukan uji efektivitas kandungan anti bakteri dari bajakah terhadap bakteri Pseudomonas Aeruginosa. Tujuan penelitian untuk mengetahui konsentrasi yang terbaik yang dapat menghambat pertumbuhan kedua bakteri tersebut. Metode penelitian menggunakan metode Disc Diffusion (Kirby-Bauer) untuk menguji bakteri Pseudomonas Aeruginosa dengan memakai kertas cakram yang didalamnya  terdapat ekstrak akar kayu bajakah  pagar kemudian diletakkan ke media kultur (MHA) metode ini berguna untuk mengamati diameter zona hambat ekstrak kemudian hasilnya batch-to-batch yang baik. Metode pengolahan data yang digunakan dalam uji coba penelitian adalah Shapiro-Wilk yaitu oneway ANOVA untuk mengetahui efek antibakteri dari ekstrak daun jarak pagar dan uji Least Significant Difference (LSD) untuk mengetahui perbedaan efek antibakteri antar 2 kelompok perlakuan. Hasil penelitian yang didapatkan adalah bakteri Pseudomonas Aeruginosa memiliki nilai rata-rata lebih tinggi diameter zona hambat tertinggi pada perlakuan 100% sekitar 22,4 mm dengan menggunakan kontrol positif (Ciprofloxacin)  sebagai perbandingan dengan rata – rata 50.1 mm. Kesimpulannya adalah ekstrak kayu bajakah memiliki efektivitas pada bakteri Pseudomonas Aeruginosa.Kata Kunci : Akar Kayu Bajakah; Antibakteri; Pseudomonas Aeruginosa.AbstractBajakah Tampala (Spatholobus littoralis Hassk) is one of the most widely grown plants in Central Kalimantan but has not been widely used. The novelty in this research is to test the effectiveness of the anti-bacterial content of bajakah against Pseudomonas aeruginosa bacteria. The purpose of the study was to determine the best concentration that could inhibit the growth of the two bacteria. The research method uses the Disc Diffusion (Kirby-Bauer) method to test Pseudomonas Aeruginosa bacteria using disc paper in which there is an extract of the root of the bajakah fence then placed into culture media (MHA). -good batches. The data processing method used in the research trial was the Shapiro-Wilk one-way ANOVA to determine the antibacterial effect of jatropha leaf extract and the Least Significant Difference (LSD) test to determine the difference in antibacterial effect between the two treatment groups. The results obtained were Pseudomonas aeruginosa bacteria had a higher average value of the highest inhibition zone diameter at 100% treatment of about 22.4 mm using a positive control (Ciprofloxacin) as a comparison with an average of 50.1 mm. The conclusion is that the extract of bajakah wood has effectiveness on Pseudomonas aeruginosa bacteria.
Nanoherbal Ocimum Basilicium L Reduce Mda And Increase Sod Level In Wistar Rats Induced Stz Hanjaya Hanjaya; Sahna Ferdinand; Bungaran Sihombing; Djohan Djohan
Proceedings of Malikussaleh International Conference on Health and Disaster Medicine (MICOHEDMED) Vol. 1 (2022): Proceedings of Malikussaleh International Conference on Health and Disaster Medicine
Publisher : Faculty of Medicine University of Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/micohedmed.v1i1.22

Abstract

One of the public health problems that is very serious and requires proper treatment for sufferers is diabetes mellitus (DM). An increase in plasma glucose levels that exceeds normal limits is one of the basics for diagnosing diabetes. This study aim to determine the antidiabetic activity of Nanoherbal Extract of Ocimum Basilicum L. This is an experimental study in which the research group was divided into seven groups, each including five rats weighing 200-250 grams. Which are (normal group, negative group, metformin, nanoherbal 25, 50, 100, and 200 mg/kgBW). Rats were induced by STZ 75 mg/kgBW + NCT 120 mg/kgBW until the blood glucose is above 200 mg/dL. The highest level of SOD is the control group 63.984 ± 2,065 ng/mL and the lowest is negative group is 22,41 ± 2,06 ng/mL. For group that given treatment show that the highest SOD level is in dose 200 mg/kgBW 71,72 ± 0,90 ng/mL and the lowest is in dose 25 mg/kgBW 31,814 ± 1,11 ng/mL and the group given metformin is 68,52 ± 32,39 ng/mL. The highest level of MDA is in group control which given only STZ and NCT 37,522 ± 1,64 ng/mL and the lowest MDA level is in normal group 7.199 ± 1,415 ng/mL. however, after given extract show that MDA level decreases which show in the dosen 200 mg/kgBW 7,76 ± 1,64 ng/mL that nearly to the value of normal MDA level while the highest in the treatment group is 30,83 ± 0,961 ng/ml. In summary, Nanoherbal Extract of Ocimum Basilicum L has antidiabetic activity by increasing the level of insulin and antioxidant SOD level while reducing the MDA level
Co-Authors Angelia Armita Bungaran Sihombing Djohan Djohan Fadillah, Qori Hanjaya Hanjaya Weldy Stephan