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All Journal Herb-Medicine Journal Jurnal Ilmiah Kesehatan Masyarakat Journal of Noncommunicable Diseases (JOND)
Nazula Rahma Shafriani
Universitas 'Aisyiyah Yogyakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Pengaruh Propolis Terhadap Il-6 Pada Diabetes Melitus Tipe 2: A Literature Review Nazula Rahma Shafriani
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 3 (2021): Herb-Medicine Journal Juli 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i3.9476

Abstract

Type-2 diabetes is a metabolic disease characterized by an increase in blood sugar levels due to decreased insulin secretion by pancreatic beta cells, or inappropriate insulin action. The pathophysiology of type-2 diabetes is related to inflammatory mechanisms caused by an increase in proinflammatory cytokines such as IL-6. Propolis has an anti-inflammatory role that can influence type 2 diabetes. To determine the effect of propolis as an anti-inflammatory to the IL-6 cytokines in type 2 Diabetes Mellitus A Literature review by searching electronic databases on Pubmed, ProQuest, and Google Scholar with the keywords "propolis or bee propolis and IL-6 levels or interleukin-6 levels and diabetes type-2 or type-2 diabetes" published in 2010-2020. Based on the search results, 9 journals were found. These articles consist of 5 experimental articles and 4 RCT articles. Five databases reported a decrease in IL-6 levels and three journals stated that there was an increase in IL-6 levels in the type-2 diabetes group after being given propolis. One journal reported no significant difference. Variations in propolis administration and time in IL-6 measurements affected the tendency to decrease IL-6 levels in type 2 diabetes patients. The active components in propolis were influenced by differences in plant resources, collection season, bee species, and solvents used in the extraction. IL-6 levels in the type-2 diabetes group tended to decrease after propolis administration compared to the type-2 diabetes group without propolis administration. IL-6 levels in the type-2 diabetes group increased after propolis administration because IL-6 helps improve chronic inflammation associated with type-2 diabetes.
Pengaruh Pemberian Ekstrak Pegagan (Centella asiatica) dan Ketapang (Terminalia catappa) terhadap Kadar Interleukin-6 pada Diabetes Melitus Tipe-2 Nanda Yunia Pratiwi; Nazula Rahma Shafriani
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 2, No 1 (2022): April 2022
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (584.054 KB) | DOI: 10.52365/jond.v2i1.410

Abstract

Diabetes Melitus Tipe-2 (DM tipe-2) merupakan penyakit metabolik dengan karakteristik hiperglikemia yang terjadi akibat rendahnya sekresi insulin atau kerja insulin yang dihasilkan oleh sel beta pankreas, serta terjadinya gangguan metabolisme karbohidrat, lipid, dan protein. Hiperglikemia akan menyebabkan terjadinya inflamasi pada DM tipe-2 yang ditandai dengan peningkatan kadar sitokin proinflamasi seperti IL-6, sehingga diperlukan adanya alternatif pengobatan yang dapat menekan respon imun tersebut seperti pemanfaatan tanaman (Terminalia catappa) dan (Centella asiatica) yang berpotensi sebagai anti-oksidan dan anti-inflamasi. Penelitian ini bertujuan mengetahui pengaruh pemberian ekstrak Terminalia catappa dan Centella asiatica terhadap kadar IL-6 pada DM tipe-2. Metode penelitian ini menggunakan Literature review dengan melakukan pencarian artikel pada database Google Scholar, dan science direct dengan metode PICO yang dipublikasikan pada tahun 2011-2021. Hasil penelusuran literatur diperoleh 10 artikel yang sesuai. Artikel-artikel tersebut terdiri dari 5 artikel dengan pemberian ekstrak Terminalia catappa dan 5 artikel dengan pemberian ekstrak Centella asiatica pada DM tipe-2. Pada kelompok DM tipe-2 dengan perlakuan pemberian ekstrak Terminalia catappa atau pemberian ekstrak Centella asiatica, ditemukan kadar IL-6 dan kadar glukosa darah lebih rendah daripada kelompok tanpa perlakuan pemberian ekstrak. Variasi penambahan dosis ekstrak Terminalia catappa atau Centella asiatica berpengaruh terhadap penurunan kadar glukosa dan IL-6 pada DM tipe-2. Adanya pengaruh berupa variasi penambahan dosis ekstrak Terminalia catappa dan ekstrak Centella asiatica terhadap penurunan kadar IL-6 dapat menjadi imunomodulator dalam penekanan sel imun pada DM tipe-2 agar tidak terjadi inflamasi.
Perbandingan Kadar Rheumatoid Factor pada Lansia Obesitas dan Non Obesitas di Komunitas Gla Baiturrohmah Aini Rifa Putri; Nazula Rahma Shafriani; Arif Bimantara
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 4 No. 3 (2025): Juli 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v4i3.5969

Abstract

Aging is a biological process that all individuals undergo. Tissues gradually lose their ability to repair and maintain their normal function, leading to various physical or health problems. A common medical issue among older adults is obesity, a condition in which fat accumulates in adipose and can affect a person's health. Hyperinsulinemia, glucose intolerance, dyslipidemia, hypertension, along with rheumatoid arthritis (RA), constitute impacts that obesity can cause. Griya Lansia 'Aisyiyah Baiturrohmah is an elderly community owned by the Regional Leadership of 'Aisyiyah in Yogyakarta which carries out its routine activities two times in a week. This research aimed to compare rheumatoid factor (RF) levels in obese and non-obese elderly and the existence of a link between BMI and RF examination results. This study employed a comparative experimental design with a cross-sectional approach. The study applied complete enumeration, namely all elderly who met the predetermined criteria became research samples, namely 31 people of female gender. The analysis applied both univariate and bivariate techniques within the form of mann-whitney and chi-square tests. No significant difference in RF levels was observed between obese and non-obese elderly individuals (p=0.728). Furthermore, no significant correlation was found between BMI and RF examination results in the elderly within the GLA Baiturrohmah community (p=1.000). The community is expected to maintain an appropriate diet and physical activity because it can help improve blood circulation, muscle strength, and joint stability without putting excessive pressure on the joints.
Perbandingan Kadar Glukosa dan C-Reactive Protein (CRP) pada Lansia Obesitas dan Non-obesitas di Komunitas Griya Lansia Aisyiyah Baiturrohmah Yogyakarta Kintawarmi Kintawarmi; Nazula Rahma Shafriani; Widaninggar Rahma Putri
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 4 No. 3 (2025): Juli 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v4i3.6006

Abstract

Obesity is a condition of impaired body weight control system indicated by excessive fat accumulation in the body (i.e., exceeding 20% of ideal body weight) which can cause increased blood glucose levels and systemic inflammation. Obesity assessment can be measured using the Body Mass Index (BMI) and Waist Circumference Ratio (WC). The purpose of this study was to analyze the differences in glucose and CRP levels between obese and non-obese elderly in the Aisyiyah Baiturrohmah Elderly Home Community. This research method is comparative analytical observational, to see the comparison of Glucose and CRP levels in obese and non-obese elderly. The sample collection technique used the total sampling method with a cross-sectional approach with a total sample of 31 elderly (17 obese elderly and 14 non-obese elderly). The results of the study were in the form of primary data from the results of glucose examinations using the Point of Care Test method and CRP examinations using the latex agglutination method. The results of statistical analysis of glucose examinations using the one sample t-test showed a p-value of 0.001 which indicated a significant difference between obese and non-obese glucose levels. Meanwhile, statistical tests were not carried out on CRP because all samples were found to be non-reactive, so it was stated that no significant difference was found between the CRP of obese elderly and the CRP of non-obese elderly
Co-Authors Aini Rifa Putri Arif Bimantara Kintawarmi Kintawarmi Nanda Yunia Pratiwi Widaninggar Rahma Putri