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All Journal Indian Journal of Forensic Medicine & Toxicology
Yasser Khalil Bustanji
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Public Health

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Promising Cytotoxicity and Anticancer Activity of Capsicum Annuum Ali Al-Samydai; Yasser Khalil Bustanji; Hanan Azzam; Farah Al-Mamoori; Deniz M. Al-Tawalbe; Bashaer Abu-Irmaileh; Talal Aburjai
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16360

Abstract

Background: Cancer is the second leading cause of death globally. Most of the anticancer drugs showed poorselectivity. Medicinal plants have proven, historically, their value as a source of molecules with therapeuticpotential. Aim and objective: This study aims to optimize the method of extraction, identification, qualitativeand quantitative analysis of Capsaicin (CAP) from Jordanian Capsicum annuum (C. annuum), and toinvestigate the anticancer activity of the crude extract.Methods: The plants extract from C. annuum wasobtained by Soxhlet extraction, HPLC were used for qualitative and quantitative analysis, and Cytotoxicpotentials was investigated by Cell viability (MTT).Results: Our results showed that Hexan solventrepresented a convenient yield of extraction and the highest percentage of CAP yield with better purity ofextract in comparison with other solvents, Jordan Valley ‘’Al-Ghor’’ showed the highest percentage of CAPyield in extract. Additionally, C. annuum crude extract showed dose depended cytotoxicity activity againsta cancer cell. Conclusion, we have optimized the isolated, qualitative and quantitative analysis of CAP fromthe fruits of C. annuum growing in Jordan in fast and reproducible method.
Co-Authors Ali Al-Samydai Bashaer Abu-Irmaileh Deniz M. Al-Tawalbe Farah Al-Mamoori Hanan Azzam Talal Aburjai