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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Nommensen Journal of Medicine
Ervina Julien Sitanggang
Universitas HKBP Nommensen
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Gambaran Kepribadian Mahasiswa Fakultas Kedokteran Universitas HKBP Nommensen Angkatan 2016 Berdasarkan Keberhasilan Akademik Ervina Julien Sitanggang
Nommensen Journal of Medicine Vol 5 No 1 (2019): Nommensen Journal of Medicine
Publisher : Universitas HKBP Nommensen

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.25 KB) | DOI: 10.36655/njm.v5i1.79

Abstract

Academic success of medical students is influenced by cognitive and non-cognitive factors. Included in non-cognitive factors associated with academic success in the pre-clinical phase is the basic personality. The aim of this study was to describe the personality of Faculty of Medicine Universitas HKBP Nommensen students batch 2016 based on academic success. This research is a descriptive research. The subjects of this study were 50 students of the Faculty of Medicine Universitas HKBP Nommensen class of 2016 who were selected by the total sampling method. Personality data was obtained from the Indonesian Mental Health Test report which was undertaken by students while participating in the selection of the Faculty of Medicine Universitas HKBP Nommensen in the 2016/2017 academic year. Based on academic success in the first and second years, both students who were successful and those who did not succeed academically, the majority were in the big category for conscientiousness, while moderate for openness, extraversion, agreeableness and neuroticism domain. When compared based on academic success, in the first and second years a similar picture of personality was found in the group of students who succeeded and did not succeed academically.
Encapsulated Mesenchymal Stem Cell as Regenerative Alternative for MDR-TB: A Gene Expression Analysis of ABCG2 Efflux Christine Verawaty Sibuea; Dina Octafrida Marpaung; Ervina Julien Sitanggang; Ade Pryta Simaremare; Cindy Destasya Masal; George Azriel Buala Nama Laia; Octora Angelica Violyn Tambunan; Wanda Lucia Samosir; Cici Kres Sidabalok
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12040

Abstract

Multidrug-resistant tuberculosis (MDR-TB) poses a significant global health challenge due to poor treatment outcomes. Encapsulated mesenchymal stem cells (MSCs) have emerged as a potential alternative therapy; however, their role in modulating bacterial drug sensitivity remains unclear. This study aimed to evaluate the expression of the ABCG2 efflux pump gene in encapsulated MSCs co-cultured with MDR-TB, and to explore its implications for bacterial sensitivity to anti-tuberculosis drugs. An in vitro experimental design was employed using encapsulated MSCs cultured with MDR-TB. Total RNA was isolated, converted into complementary DNA (cDNA), and analyzed using quantitative real-time PCR (RT-PCR). Gene expression levels were quantified using the Livak (ΔΔCt) method. Results demonstrated a progressive increase in ABCG2 gene expression on days 2, 7, and 14. Although this increase may reduce the direct antibacterial capacity of MSCs, previous studies have shown that their preserved paracrine function remains beneficial for immunomodulation. These findings support the continued investigation of encapsulated MSCs as an adjunctive therapy for MDR-TB, particularly through immunoregulatory mechanisms despite increased ABCG2 expression.
Co-Authors Ade P.R. Simaremare Christine Verawaty Sibuea Cici Kres Sidabalok Cindy Destasya Masal Dina Octafrida Marpaung George Azriel Buala Nama Laia Octora Angelica Violyn Tambunan Wanda Lucia Samosir