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All Journal Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School
Rita Evalina
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Health Professions Medicine & Pharmacology

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Skin prick test reactivity in atopic children and their number of siblings Beatrix Siregar; Lily Irsa; Supriatmo Supriatmo; Sjabaroeddin Loebis; Rita Evalina
Paediatrica Indonesiana Vol 55 No 4 (2015): July 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.083 KB) | DOI: 10.14238/pi55.4.2015.189-93

Abstract

Background Some studies have shown that low birth order is a risk factor for developing atopy, although these results remain inconclusive. Those studies put forth the hygiene hypothesis, which states that early childhood infections in siblings may protect against atopy. Hence, an inverse relationship between family numbers and atopy was found. Atopy may be diagnosed from a history of atopy in an individual or his family, and can be confirmed by specific IgE for allergens or positive skin prick tests.Objective To assess for an association between skin prick test reactivity in atopic children and their number of siblings.Methods A cross-sectional study was conducted in May to June 2010 in elementary school children at the Kampung Baru District, Medan Regency, North Sumatera. Subjects were divided into two groups. Group I had children with < 3 siblings and group II had children with ≥ 3 siblings. Skin prick tests were done in 7 to 10-year-old children with a history of asthma, allergic rhinitis and atopic dermatitis. Skin prick test reactivity results were analyzed by Chi-square test.Results A total of 192 subjects were enrolled in this study, with 96 subjects in each group. Positive skin prick tests were significantly higher in subjects with <3 siblings than in those with >3 siblings (75% and 53.1%, respectively; P=0.003).Conclusion Atopic children with <3 siblings had more positive skin prick tests than children with >3 siblings.
Peran zink terhadap sistem imun anak Nova Yulia Rita; Rita Evalina; Lily Irsa
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 46, No 2 (2013): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

The human body consists of elements of macro and micro elements. One of the many trace elements are zinc beside iron. It has biologic immunostimulatory, which is a mineral that can stimulate immune function, where these nutrients play an important role in keeping the immune system with the enzyme works as a catalyst, facilitating the formation of proteins and gene expression regulation. Zinc plays a role in the catalytic activity karbonase anhydrase, and is a component of over 100 enzymes of six classes of enzymes. Bioinformatics estimates that about 10% of the body protein binds to zinc. Keywords : zinc; imun system; essensial mineral
Co-Authors Beatrix Siregar Lily Irsa Nova Yulia Rita Sjabaroeddin Loebis Supriatmo Supriatmo