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Sukman T. Putra
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Ventricular function and high-sensitivity cardiac troponin T in preterm infants with neonatal sepsis Nusarintowati Ramadhina; Rubiana Sukardi; Najib Advani; Rinawati Rohsiswatmo; Sukman T. Putra; Mulyadi M. Djer
Paediatrica Indonesiana Vol 55 No 4 (2015): July 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.089 KB) | DOI: 10.14238/pi55.4.2015.203-8

Abstract

Background Hemodynamic instability in sepsis, especially in the neonatal population, is one of the leading causes of death in hospitalized infants. The major contribution for heart dysfunction in neonatal sepsis is the myocardial dysfunction that leads to decreasing of ventricular function. The combination of echocardiography and laboratory findings help us to understand the ventricular condition in preterm infants with sepsis.Objective To assess for a correlation between ventricular function and serum high-sensitivity cardiac troponin T (hs-cTnT) level in preterm infants with neonatal sepsis.Methods We prospectively studied 30 preterm infants with neonatal sepsis who were admitted to the neonatal intensive care unit (NICU) of Cipto Mangunkusumo Hospital from June 1 – August 31, 2013. The ventricular functions were measured using 2-dimensional echocardiography. The parameters of right ventricular (RV) function assessment were tricuspid annular plane systolic excursion (TAPSE) and RV myocardial performance index (MPI). For left ventricular (LV) performance, we assessed ejection fraction (EF), fractional shortening (FS), and LV-MPI. Serum hs-cTnT was measured and considered to be a marker of myocardial injury.Results Subjects had a mean gestational age of 31.5 (SD 2.18) weeks and mean birth weight of 1,525 (SD 437.5) g. The mean LV function measured by MPI was 0.281 (SD 0.075); mean EF was 72.5 (SD 5.09)%; and mean FS was 38.3 (SD 4.29)%. The RV function measured by TAPSE was mean 6.85 (SD 0.94) and that measured by MPI was median 0.255 (range 0.17-0.59). Serum hs-cTnT level was significantly higher in non-survivors than in survivors [282.08 (SD 77.81) pg/mL vs. 97.75 (24.2-142.2) pg/mL, respectively P =0.023]. There were moderate correlations between LV-MPI and hs-cTnT concentration (r=0.577; P=0.001), as well as between RV-MPI and hs-cTnT concentration (r=0.502; P=0.005). The positive correlation between LV and RV-MPI in neonatal sepsis was strong (r=0.77; P <0.001).Conclusion Left and right ventricular MPI show positive correlations with hs-cTnT levels. Serum hs-cTnT is significantly higher in non survivors. As such, this marker may have prognostic value for neonatal sepsis patients.
Comparison of minimal inhibitory and bactericidal capacity of oral penicillin V with benzathine penicillin G to Streptococcus beta--hemolyticus group A in children with rheumatic heart disease Burhanuddin Iskandar; Bambang Madiyono; Sudigdo Sastroasmoro; Sukman T. Putra; Mulyadi M. Djer; Anis Karuniawati
Paediatrica Indonesiana Vol 48 No 3 (2008): May 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.281 KB) | DOI: 10.14238/pi48.3.2008.152-5

Abstract

Background Injection ofbenzatine penicillin G (BPG) every 28days is still the drug of choice for secondary prevention of rheu-matic heart disease (RHD). BPG sometimes poses problems dueto pain at the injection site, possible anaphylaxis, and is not alwaysavailable. Some centers choose oral penicillin over BPG.Objectives To compare minimal inhibitory capacity (MIC) andminimal bactericidal capacity (MBC) of oral penicillin V serumwith those of BPG among SGA infected RHD.Methods This was a clinical trial with crossover design study tocompare MIC of penicillin V and BPG. Outcome measures wereMIC and MBC. Statistical analysis was performed using pairedt-test and wilcoxon test.Result There were 32 subjects consisted of 17 males and 15females. The mean value of MIC and MBC serum of penicillinV were 0.031 and 0.125. The mean value of MIC and MBCserum of BPG3 were 0.094 and 0.031. Respectively the MICof penicillin V was similar to that of BPGy The mean value ofMIC and MBC of BPG4 were 0.125 and 0.250. Respectively theMIC of penicillin V was significantly higher than that of BPG 4.The MBC of penicillin V was significantly higher than that ofBPG 4. The MIC ofBPG 3 was similar to that ofBPG 4• The MBCof BPG 3 was similar to that of BPG 4.Conclusions The MIC of penicillin V was similar to that ofBPG 3,the MBC of oral penicillin V was higher than that ofBPG 3• TheMIC and MBC of penicillin V was higher than those of BPG 4.
Diagnostic Value of Plain Chest Roentgenogram in Rheumatic Mitral Valvular Disease Bambang Madiyono; Indra Sugiarno; Sukman T. Putra; Sudigdo Sastroasmoro; Widhodho T. Karyomanggolo; Hariarti S. Pramulyo
Paediatrica Indonesiana Vol 36 No 5-6 (1996): May - June 1996
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.494 KB) | DOI: 10.14238/pi36.5-6.1996.102-8

Abstract

Rheumatic fever and rheumatic heart disease are still important commu­nity health problem in developing countries. The aim of this diagnostic test was to deter­mine the diagnostic role of plain chest roentgenogram in patients with rheumatic mitral valvular disease. Subjects were patients with rheumatic mitral disease without other val­vular lesions, congenital heart disease, or anemia, who visited the out-patient clinic, De­partment of Child Health, Cipto Mangunkusumo Hospital, Jakarta, between June and August 1995. There were 52 subjects enrolled to this study. Determination of type valve lesions, the presence of left atrial dilatation, and cardio-thoracic ratio (CTR) were per­formed from plain chest film by 2 pediatric radiologists using a semiquantitative table. The results were compared with échocardiographie findings used as gold standard. The chest plain roentgenogram accuracy in determining valvular lesion was 77% (090%; 67.4%-86.6%). Chest plain roetgenogram diagnostic index in discovering left atrial dilata­tion gave excellent result (>80%). The correlation between CTR and left ventricular mass (LVM) was 0,63 (p<0.001) in all rheumatic mitral valvular lesions. We conclude that plain chest roentgenogram still has its place in determining type of rheumatic mitral valvular lesion, and it has some help in the management of patients with rheumatic mitral valve disease.
Co-Authors Anis Karuniawati Bambang Madiyono Burhanuddin Iskandar Hariarti S. Pramulyo Indra Sugiarno Mulyadi M. Djer Najib Advani Nusarintowati Ramadhina Rinawati Rohsiswatmo Rubiana Sukardi Sudigdo Sastroasmoro Widhodho T. Karyomanggolo