Garuda - Garba Rujukan Digital

Theodorus Theodorus

Department of Child Health, Sriwijaya University Medical School

Author-ID : 3452115

Health Professions Medicine & Pharmacology

Published : 3 Documents Claim Missing Document

Claim Missing Document

Articles

Relationship between small for gestational age and aortic intima-media thickness in newborns Ahmad Bayu Alfarizi; Ria Nova; Julniar Mawardi Tasli; Theodorus Theodorus
Paediatrica Indonesiana Vol 54 No 1 (2014): January 2014
Publisher : Indonesian Pediatric Society

Background Small for gestational age (SGA) has been associatedwith adult cardiovascular disease. Small for gestational agenewborns may undergo early aortic wall intima-media thickening(aIMT) in utero.Objective To determine the relationship between SGA as a riskfactor for increased aIMT, as a sign of atherosclerosis onset.Methods We conducted a case-control study in the Neonatal Wardand Rooming-in Nursery at Dr. Mohammad Hoesin Hospital,Palembang, between April to June 2012. Subjects were allocatedto either the case group (aIMT 2: 0.9 mm) or to the controlgroup (aIMT <0.9 mm). Newborns were classified as SGA iftheir birthweight (BW) was < l O'h percentile, and appropriatefor gestational age (AGA) if their BW was between lQth - 90'hpercentile, according to the Lubchenco curve. Abdominal aorticintima-media thickness was measured by echocardiographyexamination.Results The case and control groups consisted of 30 n ewbornseach. The proportion of SGA newborns was higher in the casegroup than the control group. The likelihood of infants in the casegroup being SGA was significantly higher compared to the controlgroup, with odds ratio of 10.8 (95%CI 3,26 to 35, 72) . The meanaIMT was significantly higher in SGA than in AGA infants, 0.9(SD 0.16) mm vs. 0.8 (SD 0.13) mm, respectively, with a meandifference of 0, 13 (9 5% CI 0, 050 to 0,209 mm; P"" 0,02).Conclusion Increased aIMT is more likely found in SGA newborns.

Ibuprofen vs. indomethacin for persistent ductus arteriosus closure in preterm infants Deny Salverra Yosy; Ria Nova; Julniar M. Tasli; Theodorus Theodorus
Paediatrica Indonesiana Vol 53 No 3 (2013): May 2013
Publisher : Indonesian Pediatric Society

Background Indomethacin and ibuprofen are anti-prostaglandinE2 agents administered for persistent ductus arteriosus (PDA)closure. Ibuprofen has weaker cyclooxygenase-1 inhibitor affinitythan that of indomethacin, causes decreased gastrointestinalcirculation, as well as brain and kidney side effects.Objective To compare the efficacy of oral ibuprofen andindomethacin for PDA closure in preterm infants.Methods A randomized double-blind controlled trial on preterminfants with PDA was performed in Moehammad HoesinHospital, Palembang, from October to December 2011. Persistentductus arteriosus was diagnosed by echocardiography. Subjectswere divided into two groups, and received either ibuprofen orindomethacin. Ibuprofen was given at a dose of 10 mg/kgBW /don day 1 and 5 mg/kgBW /d on days 2 and 3. Indomethacin wasgiven in three doses over 24 hour-intervals; the first dose was 0.2mg/kg, and the second and third doses were 0.1 mg/kg each.Results Sixty infants were enrolled in this study, 36 boys (60%)and 24 girls ( 40%). Fifty-two subjects completed the study protocol.Ductus arteriosus (DA) closure after treatment was observed in 22out of 26 subjects in the ibuprofen group and 19 out of 26 subjectsin the indomethacin group (P= 0.04). The mean DA diameterreductions after administration of ibuprofen or indomethacin were0.40 (SD 0.16) mm and 0.30 (SD 0.21) mm, respectively (95%CIof differences0.05 to0.17; P= 0.04). Serum creatinine was elevatedin the indomethacin group following treatment compared to theibuprofen group [P = 0.002, 95% CI of differences 0.06 to 0.27].Ductus arteriosus reopening occurred in 4 out of 19 subjects in theindomethacin group, while n one in the ibuprofen group .Conclusions Ibuprofen is better than indomethacin, in terms ofhigher PDA closure rate and mean DA diameter reduction aftertreatment. In additional, indomethacin has significantly greaterincrease in mean serum creatinine level after treatment thanibuprofen.

Risk factors for patent ductus arteriosus in preterm neonates Novia Bernati; Ria Nova; Julniar M. Tasli; Theodorus Theodorus
Paediatrica Indonesiana Vol 54 No 3 (2014): May 2014
Publisher : Indonesian Pediatric Society

Background The reported prevalences of patent ductus arteriosus(PDA) in preterm neonates vaty, and are currently unknown inPalembang. Birth weight, ges tational age, asphyxia, histoty ofantenatal steroid use, hyaline membrane disease (HMD), raceand ethnicity, are potential risk factors for PDA.Objective To determine the prevalence of PDA and its riskfactors in preterm neonates at Mohammad Hoesin Hospital,Palembang.Methods This cross-sectional study was conducted from October2011 to April 2012. Echocardiographic examinations wereperformed on 242 preterm neonates aged 15 hours to 7 days. Datawas taken from medical records and interviews, and analyzed byChi square and logistic regression analyses.Results Patent ductus arteriosus was found in 142 (58.7%)preterm neonates with a prevalence ratio of 1.43. Neonates withbirthweight ::;;2,000 grams tended to have 1.9 (95% CI 1.17 to3.32) rimes higher risk for PDA (P=0.01). Neonates ::;;JO weeksgestation were also at 1.9 rimes higher risk for PDA (P=0.16).Probabilities for PDA occurrence in neonates with asphyxia,without antenatal corticosteroids and HMD were 1.6 (95%CI 1.13 to 3.36) rimes, 1.3 (95%CI 0.73 to 2.50) times and 2.2(95%CI 1.29 to 3.72) rimes higher risk for PDA, respectively(P=0.22, 0.41, and 0.005, respectively).Conclusion Birth weight and HMD are statistically significantrisk factors of PDA, but the more significant one is HMD.

Title

Found 3 Documents
Search

Abstract

Abstract

Abstract

Title Search

Found 3 Documents Search

Abstract

Abstract

Abstract

Title

Found 3 Documents
Search