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Sri Mulatsih
Department of Child Health, Medical School, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta
Health Professions Medicine & Pharmacology

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Correlation between C--reactive protein and serum iron levels in children with pneumonia I Gd. Oki Novi Purnawan; Ida Bagus Subanada; Sri Mulatsih
Paediatrica Indonesiana Vol 52 No 1 (2012): January 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.187 KB) | DOI: 10.14238/pi52.1.2012.38-42

Abstract

Background Pneumonia is an infectious disease often occuringin children under five years of age. At the time of infection,pro-inflammatory cytokines are released. It is thought that thesepro-inflammatory cytokines cause changes to iron homeostasisin the body.Objective To determine a correlation between CRP and serumiron levels in children with pneumonia.Methods An analytical, cross-sectional study was performedin children aged 6 months-5 years with severe pneumonia atSanglah Hospital, Denpasar, Bali from April-November 2010.Laboratory examinations included CRP and serum iron levels.The correlation between CRP and serum iron levels was analyzedby Pearson's correlation.Results From 69 children with severe pneumonia, 23 childrenfulfilled the inclusion criteria. Subjects' median CRP level was9.22 mg/Land median serum iron level was 25.55 ug/dL. Thecoefficient correlation between CRP and serum iron levels was-0.580 (P=0.004). The determination coefficient value was0.316.Conclusion In children with severe pneumonia, CRP levelcorrelates negatively with serum iron levels. [Paediatr lndones.2012;52:38-42).
Co-Authors I Gd. Oki Novi Purnawan Ida Bagus Subanada