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Pudjo Hagung Widjajanto
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Circumcision in boys with mild Hemophilia A – the Yogyakarta experience Pudjo Hagung Widjajanto; Ridwan Tjandra Sugiarto; Sutaryo Sutaryo; Kaiser Ali
Paediatrica Indonesiana Vol 47 No 2 (2007): March 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.49 KB) | DOI: 10.14238/pi47.2.2007.71-3

Abstract

Background In boys with hemophilia, there is a risk ofhemorrhage resulting from circumcision. There has been nostandardised management in Indonesia. We report our experiencewith 4 hemophiliac boys who underwent circumcision at Dr.Sardjito General Hospital, Yogyakarta, in south-central Java.Objective To develop a safe, practical and accessible method toprevent bleeding in boys with hemophilia undergoing circumcisionin Indonesia.Methods Written informed consent was obtained from parentsrequesting the procedure. All boys had mild Hemophilia A (VIII:C level >7.8 U/ml) diagnosed at a median age of 4.4 years (range0.75–9 years). Median age at time of circumcision was 7.5 years(range 0.8–12 years).Results There were no intraoperative or post-circumcisionbleeding problem encountered in any of the patients, who weredischarged from hospital three days post-surgery. On follow upeight days and 12 days post-circumcision, they remained free ofcomplications.Conclusion Circumcision can be safely performed in boys withmild Hemophilia A following adequate pre-operative planningand prophylactic therapy. A standardised protocol for theYogyakarta Bleeding Disorders Program. evolving from thisexperience, is being planned.
Leukemia Myeloblastik Akut: Luaran Terapi di RSUP DR. Sardjito, Yogyakarta, 2004-2008 SITI AURELIA NURMALASARI; PUDJO HAGUNG WIDJAJANTO; SRI MULATSIH; IGNATIUS PURWANTO
Indonesian Journal of Cancer Vol 6, No 2 (2012): Apr - Jun 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i2.163

Abstract

Latar belakang: insiden Leukemia Myeloblastik Akut (LMA) anak meningkat dari tahun ke tahun, namun keberhasilan terapi masih rendah. Tujuan: mengetahui overall survival pasien LMA anak dan faktor prognosis yang mempengaruhi luaran terapi di RSUP DR. Sardjito Yogyakarta, Januari 2004 - Desember 2008. Metode: anak usia < 15 tahun dan baru terdiagnosis LMA dimasukkan dalam penelitian ini. Faktor prognosis meliputi jumlah lekosit saat diagnosis dan status gizi. Analisis overall survival menggunakan metode Kaplan-Meier. Faktor prognosis dianalisis menggunakan regresi Cox. Hasil: terdapat 56 (63,6%) pasien menjalani kemoterapi dengan modifikasi protokol NOPHO-AML 93. Didapatkan 19 (33,9%) pasien meninggal, 4 (7%) relaps, 32 (57%) drop out, dan 1 (2%) survive. Median survival 3,05 bulan (10 hari - 2,8 tahun). Overall survival 3 tahun adalah 19 10%. Kesimpulan: prognosis LMA anak di institusi kami masih buruk. Progresivitas penyakit, toksisitas obat, dan belum memadainya supportive care berperan dalam kematian pasien LMA anak.Kata kunci: LMA anak, faktor prognosis, overall survival.
Co-Authors Ignatius Purwanto Kaiser Ali Muhammad Agus Muljanto Ridwan Tjandra Sugiarto SITI AURELIA NURMALASARI Sutaryo Sutaryo