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Sudaryat S.
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Health Professions Medicine & Pharmacology

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Effect of oral vitamin K prophylaxis on prothrombine time and activated partial thromboplastin time: a randomized controlled comparison with an intramuscular vitamin K in infants V. Lily Limantara; Sudaryat S.; I. B. Mudita; W. Retayasa; M. Kardana
Paediatrica Indonesiana Vol 47 No 3 (2007): May 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.269 KB) | DOI: 10.14238/pi47.3.2007.109-14

Abstract

Background Low plasma concentration of vitamin K in thenewborn accounts for serious bleeding in the neonatal period andearly infancy. The aim of prophylactic vitamin K is to preventbleeding. Oral prophylaxis is preferable to intramuscular (IM)administration because oral administration is less expensive andless traumatic.Objective To compare oral vs. intramuscular vitamin K onprothrombine time (PT) and activated partial thromboplastin time(APTT) during the first 60 days of life.Methods We randomized newborn infants to either receive oralvitamin K 2 mg at birth and repeated at 7 and 30 days of life orthe 1 mg intramuscular vitamin K. PT and APTT were monitoredat 0, 15, and 45 days of age. Independent t-test, repeatedmeasurement, and regression analysis were used for statisticalanalyses and comparison of the results.Results Fifty infants were assigned into the oral group and 50 tothe IM group. All participants completed 60 days of study. BothPT and APTT decreased after administration of oral or IM vitaminK, and the values did not differ significantly at any time pointand through the period of investigation. Using regression analysisit was shown that only vitamin K administration was correlatedwith PT and APTT with P value were 0.044 and 0.036,respectively. During 60 days of study, there was no hemorrhagicdiathesis in both groups.Conclusions Through the first 60 days of life, 3 doses of oralvitamin K maintain hemostasis by decreasing PT and APTT ininfants at values equal to those achieved by the intramuscularpreparation. Diathesis hemorrhagic event did not occur in bothgroups.
Necrotizing Enterocolitis in an Asphyxiated Premature Infant Sunarka Sunarka; Hamid S.; Sudaryat S.
Paediatrica Indonesiana Vol 36 No 5-6 (1996): May - June 1996
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.797 KB) | DOI: 10.14238/pi36.5-6.1996.126-31

Abstract

A case of NEC in a six days old asphyxiated premature infant was reported. The diagnosis was based on predisposing factors including low weight infant, severe ash- pyxia, her mother sufferef from fever and premature rupture of the amniotic membrans more than 24 hours. Clinical features include abdominal distention with discoloration of the abdominal wall, vomiting bloody stool, sclerema, temperature instability, jaundice, and respiratory distres. Plain abdominal X ray examination showed significant intestinal distention, and hiponatremia. The patient was treated with supportive therapy and sur­gical intervention was not done because the poor condition of the patient. The prognosis of NEC depend on the severity of disease, with mortality rate varies from 0 to 64%. The prognosis of our case is not good and on January 28, 1904 she died.
Co-Authors Hamid S. I. B. Mudita M. Kardana Sunarka Sunarka V. Lily Limantara W. Retayasa