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Ni Made Sumiartini
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Health Professions Medicine & Pharmacology

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Efficacy of dexamethasone for lung maturity in preterm delivery in association with lamellar bodies count Ni Made Sumiartini; Hendra Santoso; Wayan Retayasa; Made Kardana
Paediatrica Indonesiana Vol 47 No 3 (2007): May 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.286 KB) | DOI: 10.14238/pi47.3.2007.115-9

Abstract

Background Organ immaturities in preterm infants may result inperinatal death. One of the diseases is respiratory distress syndrome(RDS) which is caused by lung immaturity. Dexamethasone is oftenused to accelerate maturity of infant lungs.Objective To determine the efficacy of dexamethasone on lungmaturity measured by lamellar bodies count.Methods A quasi experimental study was done at PerinatologyDivision, Department of Child Health, Medical School, UdayanaUniversity, Sanglah Hospital, Denpasar. We recruited 72 subjects;36 subjects were given four times intramuscular dexamethasone5 mg every twelve hours before delivery. Thirty six subjects whodid not receive dexamethasone belonged to control group. Infants’lungs maturity assessment was performed using lamellar bodiescount taken from amniontic fluid.Results The gestational age ranged between 28 to 36 weeks, withthe mean gestational age in dexamethasone group was 32.2 (SD1.76) weeks and that in control group was 31.7 (SD 2.65) weeks.The efficacy of dexamethasone therapy on lung maturity wassignificant with Fisher’s exact test P<0.0001, 95%CI 2.546;11.173. Using multivariate logistic regression analysis, there wassignificant correlation between dexamethasone and lung maturitymeasured by lamellar bodies count [OR=239.39; P<0.0001,95%CI 22.12;526.53].Conclusion Administration of dexamethasone in pregnantwomen during preterm delivery significantly improves lungmaturity measured by lamellar bodies count.
D+ hemolytic uremic syndrome Ni Made Sumiartini; I Nyoman Lila; I Ketut Suarta
Paediatrica Indonesiana Vol 44 No 2 (2004): March 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi44.2.2004.80-4

Abstract

Hemolytic uremic syndrome (HUS) is characterized by anemia microangiopathy, thrombocytopenia, and acute renalfailure, predominantly occurs in childrenyounger than 4 years of age. It is the most commoncause of acute renal failure in children.1,2 HUS is dividedinto two categories, the epidemic type which isaccompanied by enteritis (D+HUS) and the sporadictype which is not accompanied by enteritis (D-HUS).The pathogenesis is unknown, but available evidencestrongly suggests endothelial cell damage in the organs.
Co-Authors Hendra Santoso I Ketut Suarta I Made Kardana I Nyoman Lila Wayan Retayasa