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All Journal Jurnal Farmamedika (Pharmamedica Journal)
Abdul Ghoni
Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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POTENSI ENZIM TRANSGLUTAMINASE SEBAGAI GEL PENYEMBUH LUKA STADIUM II PADA AYAM RAS JANTAN Sitaresmi Yuningtyas; Winugroho; Abdul Ghoni
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (702.933 KB) | DOI: 10.47219/ath.v1i1.44

Abstract

The transglutaminase (EC 2.3.2.13) is an enzyme that catalyses an acyl transfer reaction of the γ-carboxiamide groups glutamine residues in proteins, peptides and various primary amines. Enzyme transglutaminase helps to stabilized the fibrin monomer during the process of blood clotting. This research was to determine the activities of the wound healing process stage II in male broilers given the transglutaminase enzyme sample gels. In this researchgel formulationmadeenzymetransglutaminase1%, 3%, 5% and7%. Transglutaminaseenzymegelpreparationorganoleptictestandhomogeneity test. Furthermore,thegel formulationapplied to themalebroilersownwoundsstage II. Transglutaminaseenzymegel formulationhad ahomogeneoustexture, white, odorlesstypicalenzymetransglutaminase, andhad apH rangefrom 6.2 to 6.7. The percentagereduction inwoundlength ofstage IIinmalebroilersbyenzymetransglutaminaseperfomedgel1%, 3%, 5% , 7% and Bioplacenton® gel (positive control) were 80.54%, 99.00%, 99.67%, 87.25%, and 99.33% respectively. Based on analysis statisticsofANOVA, percentage reduction inwoundlength ofstage IIby treatment withtransglutaminasepreparationgel5% higher and significantly differentcompared totreatmentwithBioplacenton®(positive control). Hence, transglutaminaseenzymepreparations5% gelcanact as awound healerstage IIinmalebroilers.
Co-Authors Sitaresmi Yuningtyas Winugroho