I K. G. Suandi
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Cognitive development in babies with exclusive breastfeeding using Mullen Scale test I G. Maharditha; Soetjiningsih Soetjiningsih; I K. G. Suandi
Paediatrica Indonesiana Vol 48 No 5 (2008): September 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.635 KB) | DOI: 10.14238/pi48.5.2008.278-83

Abstract

Background Breast milk is the best nutrition for babies' growthand development. There are many reasons for discontinuation ofexclusive breastfeeding (BF).Objective To evaluate the impact of exclusive breastfeeding onbabies' cognitive development.Methods A cohort study was conducted for full term newbornbabies. They were evaluated for cognitive development usingMullen scale test at of 6 and 9 months; t test was used to obtainmean difference of cognitive values. Logistic regression analysiswas performed to distinguish factors associated with the cognitivedevelopment.Results One hundred and forty babies were enrolled to this study(70 babies with exclusive BF and 70 babies with non-exclusiveBF). There were 34 boys (49%) in exclusive and 37 boys (53%) innon-exclusive BF group. Mean cognitive score at age six monthswas 1.41 points higher for exclusive BF group, mean rate 174.31(SO 4.89) and 172.90 (SO 4.19) for exclusive and non-exclusive BF,respectively. Mean cognitive score at nine months was 1.49 pointhigher in exclusive BF group with mean rate 175.28 (SO 4.39) and173.82 (SO 3.80) for exclusive and non-exclusive BF respectively.Logistic regression analysis showed that exclusively breastfed babieshad higher mean Mullen cognitive score of 4. 761 (95% CI 1.341;16.907) and 4.431 (95% CI 1.313; 14.949) times at sixth and ninthmonth respectively than non-exclusive BEConclusion Exclusively breastfed babies may have higher meanscore of Mullen cognitive score at sixth and ninth months whencompared with those who are non exclusively breastfed.
The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial K. Suarca; Hendra S; B. N. P. Arhana; I K. G. Suandi
Paediatrica Indonesiana Vol 48 No 6 (2008): November 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.043 KB) | DOI: 10.14238/pi48.6.2008.374-80

Abstract

Background Suboptimal zinc intake may depress thymus function,lymphoproliferation, and T cell-dependent B-cell proliferation,which can impair antibody production. Zinc supplementation canimprove immune function and reduce morbidity.Objective To assess the effect of zinc supplementation on infants'anti-HBs titer after hepatitis B vaccination.Methods A double-blind randomized control trial of 66 healthyinfants in Pustu Dauh Puri, Denpasar Barat was conducted. Subjectswere followed from birth to three months of age and were placedinto two treatment groups using block randomization. One groupreceived zinc supplements with a standard hepatitis B vaccination(zinc group, n=33) and the other group received placebosupplements with standard hepatitis B vaccination (placebo group,n=33). The serum zinc levels were measured at baseline and atthree months. The difference in levels of anti-HBs titer between thezinc and placebo groups was the primary endpoint of this study.Results The serum zinc levels were significantly higher in the zincgroup compared to the placebo group (P = 0.017), with a meandifference of 18.76 miU/ml (95% CI 3.45 to 34.07). Regardlessof baseline serum zinc levels, the mean anti-HBs titers weresignificantly higher in the zinc group compared to the placebogroup (P <0.0001; mean difference = 495.8 miU/mL; 95%CI 362.32 to 629.44). Multivariate analysis showed that zincsupplementation was the only variable that influenced anti-HBstiter levels (P < 0.0001).Conclusion Regardless of their initial zinc serum level, infantsreceiving zinc supplements along with standard hepatitis Bvaccination have significantly higher levels of anti-HBs titersthan infants receiving hepatitis B vaccination without zincsupplements.