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Arwin AP Akib
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Health Professions Medicine & Pharmacology

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Cow’s milk allergy in patients with diarrhea Nanis S Marzuki; Arwin AP Akib; I Boediman
Paediatrica Indonesiana Vol 44 No 6 (2004): November 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.063 KB) | DOI: 10.14238/pi44.6.2004.239-42

Abstract

Background Cow’s milk allergy (CMA) might be one of the causesof diarrhea in children. Previous prospective studies found theprevalence of CMA in children aged 0-3 years between 1.1-5.2%,but data about the prevalence of CMA in children with diarrheawas very limited.Objective This study intended to estimate the prevalence of CMAin children with diarrhea.Methods Children aged 0-3 years, who came with diarrhea andconsumed milk formula were selected for further evaluation. Adiagnostic procedure was developed i.e., elimination diet with par-tially hydrolyzed formula (pHF) for 2 weeks, and then open milkchallenge. If diarrhea was not resolved with pHF, the children weregiven extensively hydrolyzed formula, or soy-based formula.Results Ninety-nine children participated in this study, 87 camewith acute diarrhea and 12 with chronic diarrhea. There were 3children (2 children with acute diarrhea and one with chronicdiarrhea) who reacted to the milk challenge.Conclusion The estimated prevalence of CMA in children withdiarrhea in our study was 3%
The prevalence of factor VIII inhibitor in patients with severe hemophilia-A and its clinical characteristics Harijadi Harijadi; Djajadiman Gatot; Arwin AP Akib
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.177-81

Abstract

Background Hemophilia is a hereditary blood-clotting disorderdue to factor VIII deficiency. Up to this date, the administration offactor VIII in preventing and managing bleeding has been the maintreatment. One of the complications, which may occur due to re-peated administrations of factor VIII, is the formation of factor VIIIantibody (factor VIII inhibitor).Objective To find out the prevalence of severe hemophilia-A withfactor VIII inhibitor and its clinical characteristics.Methods A cross-sectional descriptive study was performed onchildren with severe hemophilia-A at the National Hemophilia CareCentre, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, in June-August 2004.Results Out of 45 children studied, 16 had factor VIII inhibitor withaverage inhibitor titre of 1.15 Bethesda units (BU) (range 0.15-15BU). Most of them (12 patients) had inhibitor titre <5 BU. Chronicarthropathy was found in 17 out of 45 (37%) children with severehemophilia-A, consisting of nine patients from positive inhibitorgroup and 8 patients from negative inhibitor group. Thirty-ninepatients (86%) used an on-demand treatment pattern, among whom15 had positive inhibitor. Among patients receiving prophylactictreatment pattern, only one had positive inhibitor. There were 39patients (86%) treated using cryoprecipitate, among whom factorVIII inhibitor was found in 12, while among those treated with fac-tor VIII concentrate, the inhibitor was positive in 4/6. The averageamount of factor VIII transfused in positive and negative factor VIIIinhibitor groups was similar.Conclusion The prevalence of factor VIII inhibitor in severe he-mophilia-A patients was 35%. Chronic arthropathy occurred moreoften in patients with positive factor VIII inhibitor. Factor VIII inhibi-tor was found more frequently in patients with an on-demand treat-ment pattern and in those using factor VIII concentrate
The prevalence of atopic dermatitis history in asthmatic children Rifda Suryati; Arwin AP Akib; I Boediman; Abdul Latief
Paediatrica Indonesiana Vol 46 No 4 (2006): July 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.4.2006.164-9

Abstract

Background Atopic dermatitis (AD) is a risk factor of asthma. Thereis still limited information about its prevalence and characteristicsin asthmatic children.Objective To find out the prevalence of AD history in asthmaticchildren.Methods This was a cross-sectional study conducted at the De-partment of Child Health, Cipto Mangunkusumo Hospital, Jakarta,from July until December 2004. Patients with asthma who were ator less than 5 years of age were included in the study. The parentshad completed study questionnaire about asthma, AD, and someinformation about atopic family history, the food history in infantperiod and environment factors.Results Ninety children met the inclusion criteria. Male and femaleratio was 1.5:1. Most of subjects reported onset of asthma in 12-36 months of age. The history of AD was found in 26% of asth-matic children with quite similar number for both sexes. All sub-jects had atopic family history with asthma as the most commonmanifestation. The environment factors contributed to this eventwere mother’s diet containing allergen and smoking history in familyduring pregnancy and lactation period. More than half of subjectshad no breast-feeding. Solid food and formulated milk had beenearly-introduced.Conclusion History of AD is found in 26% asthmatic children.The percentage of characteristic distribution of factors which hadbeen assumed has a role in asthma and AD was similarly equalbetween subjects with and without history of AD
Incidence of HIV-infected infants born to HIV- infected mothers with prophylactic therapy: Preliminary report of hospital birth cohort study Nia Kurniati; T Nilamsari; Arwin AP Akib
Paediatrica Indonesiana Vol 46 No 5 (2006): September 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.491 KB) | DOI: 10.14238/pi46.5.2006.209-13

Abstract

Background Human immunodeficiency virus (HIV) is expandingrapidly and was reported double in several places in Indonesia Toour knowledge, reports regarding HIV-infected infants are stillscarce.Objectives To investigate the incidence of HIV-infected infantsborn to HIV- mothers who had received prophylaxis therapy at birth.Methods A prospective hospital-based cohort study was held fromJanuary 2003 until December 2004 in Cipto Mangunkusumo Hos-pital, Jakarta. The inclusion criteria were mothers with positive HIVand their infants had been given anti retroviral (ARV) therapy. Thebabies were followed up monthly and the status of infection wasdetermined by PCR at the age of 4 weeks and 6 months. Outcomewas measured based on PCR assays or clinical signs of HIV in-fection.Results The mothers’ age ranged from 19 to 27 years. All of themwere carrying their first child and only 41% mothers took ARV pro-phylaxis. Almost all mothers underwent caesarean section and theinfants had formula feeding. HIV infection was diagnosed in 7 in-fants and 2 of them had RNA assays more than 5,000 copies/ml.Six infants were negatives whereas 3 infants were diagnosed asindeterminate HIV infection and needed further examination. Oneneeded no further investigation as the mother was seronegative.Conclusions Preventing HIV transmission from mother to infantcan be done by giving ARV during prenatal, intrapartum, and post-natal period to the newborn. In our hospital, transmission was con-firmed in 6 of 17 infants. Unison protocol must be used and popu-lation of HIV-pregnant mother must be registered in order to knowhow high the transmission rate among Indonesian HIV people
Co-Authors Abdul Latief Djajadiman Gatot Harijadi Harijadi I Boediman Nanis S Marzuki Nia Kurniati Rifda Suryati T Nilamsari