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Cissy B. Kartasasmita

Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java

Author-ID : 3468698

Health Professions Medicine & Pharmacology

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Community trials on case management of acute respiratory infections (ARI) in rural villages Cissy B. Kartasasmita; Mintardaningsih Mintardaningsih; O. Rosmayudi; A. U. Suardi; H. Sukandar
Paediatrica Indonesiana Vol 41 No 9-10 (2001): September 2001
Publisher : Indonesian Pediatric Society

A community trial was conducted in two rural subdistricts in Subang, West Java, Indonesia, i.e., Cisalak as the intervention area and Sagalaherang as reference area. The study aimed to evaluate the usefulness new version of case management on acute respiratory tract infections (ARI). All babies born between January and December 1994 were enrolled in the study, and followed for 6 to 12 months. The field workers visited the babies every 2 weeks. They examined the babies and interviewed mothers about ARI symptoms, by using a pretested questionnaire. During that period 969 babies were born, 53.3% in Cisalak and 46.7% in Sagalaherang; 548 of them were followed for 12 months; however, only 263 among them had complete data. The morbidity of ARI increased with increasing age; there was no difference between those two study areas. The prevalence of ARI at the age of less than 3 months was 35.1% and 32.7%; between 4 to 6 months 49.9% and 45.3%; between 7 to 9 months 47.0% and 45.9% ; and between 10 to 12 months 53.7% and 50%, for Cisalak and Sagalaherang, respectively. Nevertheless, the mortality in Sagalaherang was higher than in Cisalak Â (118 per 1000 and 78 per 1000, respectively), and the pneumonia-related deaths were 64.8% and 52.5%, respectively. The age specific death rate for pneumonia was high among babies of less than 3 months of age, i.e., 68.5% and 57.2%, respectively. We conclude that mothers and primary health care workers in rural areas should be taught and encouraged to use case management of ARI, and monitoring and evaluation of the application is needed.

The quantity and quality of anti-PRP induced by the new Indonesian DTwP-HB-Hib vaccine compared to the Hib vaccine given with the DTwP-HB vaccine Novilia Sjafri Bachtiar; Kusnandi Rusmil; Sunarjati Sudigdoadi; Hadyana Sukandar; Rini Mulia Sari; Cissy B. Kartasasmita
Paediatrica Indonesiana Vol 57 No 5 (2017): September 2017
Publisher : Indonesian Pediatric Society

Background A phase II study of DTwP-HB-Hib vaccine compared to Hib (monovalent) vaccine given simultaneously with DTwP-HB vaccine has been done following the success of phase I study in infants, where the new DTwP-HB-Hib has excellent safety profiles and antibody responses in infants.Objective To evaluate the titer (quantity), avidity, and bactericidal capacity (quality of anti-polyribosylribitol phosphate/anti-PRP), of a new combined Bio Farma DTwP-HB-Hib (pentavalent) vaccine, compared to the Hib monovalent vaccine given simultaneously with the DTwP-HB vaccine (DTwP-HB+Hib).Methods The study was a prospective, randomized, open label, phase II trial. Subjects aged 6-11 weeks were allocated according to the randomization list. The pentavalent group received the DTwP-HB-Hib vaccine, while the monovalent group received the Hib monovalent and DTwP-HB vaccines separately. Immunizations were given in three doses with 28-day intervals. Blood specimens were taken before the first dose and 28 days after the last dose. We evaluated anti-PRP titers quantity (geometric mean antibody concentration/GMC) and seroprotection), followed by avidity and bactericidal (quality) testing. Titer and avidity of anti-PRP were tested using a modified version of the improved Phipps ELISA. Bactericidal capacity was evaluated using a Hib killing assay. Immune responses against other antigens in the vaccine were reported separately.Results One hundred five subjects in the pentavalent group and 106 subjects in the Hib monovalent group were tested for anti-PRP titers. Only 102 specimens for each group were available for bactericidal testing, due to insufficient volume for testing. Both vaccines induced similar anti-PRP titers, for GMC and seroprotection. Avidity increases were 82.9% and 76.4% in the pentavalent and Hib monovalent groups, respectively. Bactericidal activities were 94.1% and 89.2%, respectively. Both avidity and bactericidal activity were not significantly different between groups.Conclusion DTwP-HB-Hib vaccine induced anti-PRP quantity and quality comparable to those of the Hib monovalent vaccine given simultaneously with the DTwP-HB vaccine.

Congenital cystic adenomatoid malformation of the lung (CCAM): Report of 2 atypical cases Melinda D. Nataprawira; Cissy B. Kartasasmita; 0ma Rosmayudi; Abdulgani H.; Soebarna R.; Tri Wahyu; L. Silitonga; B. Hernowo
Paediatrica Indonesiana Vol 39 No 7-8 (1999): July - August 1999
Publisher : Indonesian Pediatric Society

Congeni~ cystic adenomatoid malformation (CCAM) presents mainly inneonates, rarely in children beyond infancy, and has been reported in adults. Two females (aged 26 months and 34 days) who had CCAM in the right and left lower lobe, respectively, are reported. One of them presented with recurrent respiratory infection and the other as newbom with respiratory distress secondary to mediastinal displacement and pulmonary compression as a result of expanding cystic lesions. Both cases had different lesions from typical neonatal cases reported in the literature.Single cyst was shown in the first case, but multiple cysts in other. The young child survived, but the baby died. All lesions had lining varied from pseudostratified columnar to cuboidal epithelium. Cartilage plates was found in the second case but not in the first. The absence of inflammation is typical in neonates' lesions, by contrast, all of our two patients had clinical and pathologic evidence of chronic inflammation. CCAM may be clinically silent in infancy and may present as pneumonia associated with cystic lesion on chest X-ray in childhood or la ter in life. To support the diagnosis, CT scanning is needed.

Knowledge, Attitude and Practice on Acute Respiratory Infections among Mothers in Two Rural Areas in Subang Subdistrict, West Java, Indonesia Cissy B. Kartasasmita; Mintardaningsih Mintardaningsih; Anna Alisjahbana; Oma Rosmayudi; S. Hadyana
Paediatrica Indonesiana Vol 39 No 11-12 (1999): November - December 1999
Publisher : Indonesian Pediatric Society

A survey was conducted in 2 rural villages in Indonesia. This study was a part of a one-year intervention study on case management of acute respiratory infections (ARI) in infants of less than 12 months old in Cisalak (VI, intervention village) and Sagalaherang (V2, control village). The aim of the study is to know the knowledge, attitude and practice (KAP) on ARI among rural villages mothers. All pregnant women and mothers with child below five years resided in those villages were included in the study. Trained field interviewers visited and interviewed mothers on several questions related to ARI using pretested questionnaire. A total of 436 and 576 mothers, with a mean age of25.4 (SD=5.7) and 26.5 (SD=5.4) years from VI and V2 respectively, were included. Most mothers had traditional beliefs that the cause of ARI was bad wind (77.3% and 73.8%, respectively), only 1.8% and 9.2% mothers know that ARI is caused by microorganisms. However, they believe that the disease is infectious (59.9% and 79.7%). Therefore, most mothers were aware and gave medication (66.5% and 36.3%) or brought the child to village health center (23.6% and 57.1%). The problems for seeking a medical help are transportation, distance and ignorance. As conclusion, we found that the present knowledge on ARI was in adequate, thus more information are needed for mothers to solve the ARI problems in rural villages.

Risk Factors for Acute Respiratory Infections in Underfive Children Cissy B. Kartasasmita; Maurits Demedts
Paediatrica Indonesiana Vol 35 No 3-4 (1995): March - April 1995
Publisher : Indonesian Pediatric Society

A longitudinal study on acute inspiratory infections was conducted from April 1988 until June 1990, in Cikutra, an urban community in the municipality of Bandung, Indonesia. The study consisted of. 3 parts: a presurvey, a cross sectional study, and a one-year prospective study. All children aged less than five years in Cikutra were included in the presurvey. A simple questionnaire was used for collecting data. In the cross sectional study 500 children were selected by stratified random sampling. Field investigators visited the children's homes and interviewed mothers using a standardized questionnaire. For the prospective study 269 children of less than 48 months of age were enrolled, and followed for one year. The prevalence of all ARI was 57-58%, mild-moderate ARl 55-56% , and severe ARJ 5%. On average the children suffered from 6.7 episodes of ARl per child per year, with a mean duration of episode of 5.3 days. Several factors showed significant relationship with the prevalence, incidence, severity of duration of ARI.

Factors Influencing Empyema in Children Cissy B. Kartasasmita; Oma Rosmayudi; Rita Wahyunarti
Paediatrica Indonesiana Vol 28 No 1-2 (1988): January - February 1988
Publisher : Indonesian Pediatric Society

Incidence of empyema in children at Hasan Sadikin General Hospital is still high, commensurate with the high number of cases of pneumonia. Thirty-seven children with empyema were studied from July 1984 to December 1985; 20 of them were females and 17 males with the age ranging between 5 months and 12 years. Three patients (8.1 %) had loculated fluid as observed on chest roentgenographs; the remainder had empyema sinistra and dextra at 43.2% and 48.6% respectively. More than 50% of the patients were undernourished (56. 7%), 5 of whom were marasmic. On admission, 89.2% complained of dyspnea, 24.3% of cough, 16.2% of high fever and 10.8% of chest pain. All patients suffered from acute respiratory tract injection (ARI) 7 to 30 days before admission, 70.3% of whom did not receive adequate medication and 5 individuals received no treatment at all. Chest tube drainage was performed on 34 patients. In the study, 3 patients died (8.1%) due to sepsis. All recovered patients had pleural thickening on chest roentgenographs on discharge. The role of under nutrition, delay of medication and inadequate treatment of ARI seemed to have an1 influence on empyema in the patients observed.

Co-Authors 0ma Rosmayudi A. U. Suardi Abdulgani H. Anna Alisjahbana B. Hernowo H. Sukandar Hadyana Sukandar Kusnandi Rusmil L. Silitonga Maurits Demedts Melinda D. Nataprawira Mintardaningsih Mintardaningsih Novilia Sjafri Bachtiar O. Rosmayudi Oma Rosmayudi Rini Mulia Sari Rita Wahyunarti S. Hadyana Soebarna R. Sunarjati Sudigdoadi Tri Wahyu

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