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J.H.P. Jonxis
Pediatric Department, State University, 59 Oestersingel, Groningen.
Health Professions Medicine & Pharmacology

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Haemoglobinopathies and their occurrence in South East Asia J.H.P. Jonxis
Paediatrica Indonesiana Vol 15 No 3-4 (1975): March - April 1975
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (393.637 KB) | DOI: 10.14238/pi15.3-4.1975.112-9

Abstract

A great number of hereditary abnormalities in the rate of haemoglobin synthesis and in structure of haemoglobins are known at the moment. Most of these abnormalities occur only in a few families and are not very important for the health of a population. Some forms occur, however, rather frequently. In Eastern Asia both alfa and beta thalassaemia cases are rather common. The alfa thalassaemia gene seems to occur in a rather high frequency in people from Chinese extraction. The beta thalassaemia gene, too, is not rare in the population of many etnic groups in South- East Asia.The symptoms of homozygocity, heterozygocity and double-heterozygocity for the different thalassaemia genes are described. In most Asia countries genetic abnormalities, causing abnormal haemoglobins, are not as common as they are for instance in many African groups. Forms of Lepore haemoglobin, Hb E, Hb Thai, Hb O, Hb S, have been found in East Asian populations, Hb Thai being rather frequent in Thailand, Hb E in Ceylon.The different clinical pictures of heterozygocity, homozygocity and double-heterozygocity for these genetic abnormalities are described.
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