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Harsoyo Notoatmojo
Department of Child Health, Medical School, Diponegoro University/Kariadi Hospital Semarang
Health Professions Medicine & Pharmacology

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Immunological Aspects of Persistent Hepatitis B in Children Harsoyo Notoatmojo
Paediatrica Indonesiana Vol 38 No 9-10 (1998): September - October 1998
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2920.316 KB) | DOI: 10.14238/pi38.9-10.1998.224-32

Abstract

We studied the immunological status of 203 children having persistent Hepatitis B (positive HBsAg) ranging in age from 6 to 14 years in Semarang Municipality. All patients showed negative results of humoral immunity (IgM anti-HBc), excluding the possibility of acute hepatitis B (HB). Cellular immunity examination using CMI skin test showed positive result in 64.9% of persistent and 65.2%, ln non-persistent HB (p>0.05). T cell examination shows significant statistical difference (p<0.01) between persistent and non-persistent HB, and there was a significant difference (p<0.01) on CD4 cell examination; indicating a difference on immunoregulation function and response repression of anti-virus between the two groups. There was no significant differences on CD4/CD8 ratio between persistent and non-persistent HB. The specific function of cytotoxic T cell also shows no significant difference between the two groups.
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