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Lydia Kosnadi
Department of Child Health, Universitas Diponegoro Medical School/Dr. Kariadi Hospital, Semarang, Central Java
Health Professions Medicine & Pharmacology

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Treatment of Acute Urinary Tract Infection in Children with Pipemidic Acid Lydia Kosnadi; Rochmanadji Widayat; Dwi Wastoro; Ari Yunanto; Ristitiati Gunawan
Paediatrica Indonesiana Vol 29 No 11-12 (1989): November - December 1989
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.898 KB) | DOI: 10.14238/pi29.11-12.1989.228-32

Abstract

Urinary tract infection in children is still an important problem in uronephrology. The disease.tends to develop recurrently and results in chronic progressive renal disease in the future. Pipemidic acid is a bactericidal quinolone derivate, with a wide spectrum against gram positive and negative bacteria. Compared with nalidixic acid, pipemidic acid proves to be more effective against Pseudomonas, E. coli, Alkali genes and Salmonella. Thirty one cases with acute urinary tract infection had been studied descriptively. The etiology revealed as follows: E. coli (45.2%), Alkaligenes (16.2%), Enterobacter (9.6%), Staphylococcus (9.6%), Pseudomonas (9.6%), Paracolon (6,5%), and Proteus (3.3%). Pipemidic acid was administered orally to these patients, 15-20 mg/kg/day divided in 2 equal doses for 10 days. Bacteriological examinations was repeated on the 6th day and 11th day treatment. The result revealed that on the 6th day of treatment, in 27 patients (87, 09%) there was no bacteriuria while on the 11th day the urine of 29 patients (93.54%) were sterile. In conclusion, a 5 day treatment of acute urinary tract infection in children with pipemidic acid is quite effective.
Hypovolemic Shock Complicating Nephrotic Syndrome in a Child Lydia Kosnadi; Rochmanadji W.; A. G. Sumantri; Trimulyo Trimulyo; M. Rofiq Anwar
Paediatrica Indonesiana Vol 28 No 9-10 (1988): September - October 1988
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.015 KB) | DOI: 10.14238/pi28.9-10.1988.209-13

Abstract

The fundamental abnormality in nephrotic syndrome is the structural and electrochemical changes that have been documented to occur in the glomerular basement membrane lead to proteinuria. It is the proteinuria itself which most likely causes hypoalbuminemia and associated complications such as infections, hypercoagulability and hypovolemia. Hypovolemia may cause postural hypotension, acute renal failure, circulatory collaps or sudden death. An eleven-year-old boy was referred to the Child Health Department of Dr. Kariadi Hospital Semarang with a diagnosis of corticosteroid resistant nephrotic syndrome and acute renal failure. Physical examination showed a severely ill boy with general edema, shock, hemoconcentration, hypoalbuminemia, hypercholesterolemia, massive proteinuria and disturbed renal function. The treatment consisted of infusion of dextrose 10% followed by human plasma and furosemide to restore plasma volume and enhance urine production. Two days later he was in better condition, normovolemia, slight edema, good diuresis, but his blood pressure increased, and ophtalmologic examination supported the diagnosis of grade I hypertensive retinopathy. Intravenous clonidine and furosemide were given and were very effective. Kidney biopsy revealed minimal lesion with slight proliferation.
Co-Authors A. G. Sumantri Ari Yunanto Dwi Wastoro M. Rofiq Anwar Ristitiati Gunawan Rochmanadji W. Rochmanadji Widayat Trimulyo Trimulyo