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Taslim E. Soetomenggolo
Department of Child Health, Universitas Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
Health Professions Medicine & Pharmacology

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Peripheral Neuropathy in Patients with Acute Leukemia Treated with Vincristine Taslim E. Soetomenggolo
Paediatrica Indonesiana Vol 35 No 3-4 (1995): March - April 1995
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (750.532 KB) | DOI: 10.14238/pi35.3-4.1995.101-9

Abstract

Between December 1993 and December 1994, 46 patients with acute leukemia treated with vincristine were evaluated for the possibilities of peripheral neuropathy. Of the 46 patients, 39 patients had acute lymphoblastic leukemia, and 7 had acute non-lymphoblastic leukemia. All patients had received vincristine; 29 (63%) of the 46 patients had it for 5 - 9 weeks, and 17 (37%) had it for 4 weeks or less. rn 10 (21.7%) patients peripheral neuropathy was detected clinically, and in 35 patients (76%) the neuropathy was detected by electrodiagnostic examination. No evidence of neuropathy was detected in 11 patients. The electrodiagnostic examination was more sensitive than the clinical examination. Pe1ipheral neuropathy, either detected clinically or by means of electromyography, occurred mostly in patients with the dosage of vincristine of 5-20 mg, and the duration of treatment of 5-9 weeks.
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