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T. H. Rampengan
Department of Child Health, Universitas Sam Ratulangi Medical School/Gunung Wenang Hospital, Manado, North Sulawesi
Health Professions Medicine & Pharmacology

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Comparative efficacy study of combination fansidar-sulphate-quinine and fansidar-hcl-tetracycline in falciparum malaria in children above 7 years old K. Silitonga; T. H. Rampengan
Paediatrica Indonesiana Vol 31 No 3-4 (1991): March - April 1991
Publisher : Indonesian Pediatric Society

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Abstract

The objective of this study is to compare the results of treatment of children with falciparum malaria with the combinations of fansidar-su/phate quinine and fansidar-chlortetracycline as an alternative treatment of chloroquine'resistant falciparum malaria. This study was carried out prospectively on 45 cases with the age equal or above 7 years, who had been admitted in the Pediatric Department, Gunung Wenang Hospital, Manado, during the period of January 1989- December 1989. Twenty three cases had been treated with fansidar - sulphate quinine and 22 cases with fansidar-chlortetracycline, all of them underwent blood examinations for malaria for 7 consecutive days (day 0-8). Asexual parasitemia and fever in the fansidar-sulphate quinine group significantly disappeared more rapidly than in the fansidar-chlortetracycline group (P <0.03 and <0.005). There occurred neither drug resistance nor serious side effect in both groups.
The efficacy of sulphate quinine compared to fansidar in treating falciparum malaria in children 6 months – 7 years old M. Mogi; T. H. Rampengan
Paediatrica Indonesiana Vol 31 No 3-4 (1991): March - April 1991
Publisher : Indonesian Pediatric Society

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Abstract

From January 1989 until February 1990, 65 children suffering from falciparum malaria without complikation at the Department of Child Health Medical School Sam Ratulangi University/Gunung Wenang Hospital Manada were randomly allocated into 2 groups. The first group was treated with sulphate quinine based on the dose of 30 mg/kgbw/day in 3 divided doses and the other one was treated with single dose fansidar (sulphadoxine-pyrimethamine) based on the dose of sulphadoxine 20-30 mg/kgbw/day. The group treated with quinine showed much shorter duration of parasitemia compared with the group treated with fansidar. Fever subsided more rapidly in children treated with quinine compared with those treated with fansidar.
Comparative efficacy of combination fansidar-sulphate-quinine and fansidar-cbloroquine in mixed malaria infections of P. falciparum - P. vivax in children A. Liando; T. H. Rampengan
Paediatrica Indonesiana Vol 31 No 3-4 (1991): March - April 1991
Publisher : Indonesian Pediatric Society

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Abstract

From January 1987 until March 1990, 61 children suffering from mixed malaria infections of P. falciparum and P. vivax entered the Department of Child Health Medical School Sam Ratulangi University/Gunung Wenang General Hospital, Manado. Only 41 patients were evaluated as 20 patients did not fulfill the inclusion criteria. Twenty patients were treated with fansidar-quinine (Group I), and 21 patients with fansidar chloroquine (Group II). In group II, the asexual form of P. vivax disappeared in 2 days after having been treated with fansidar-chloroquine. Conversely, in group I the asexual form of P. vivax disappeared after 5 days o[ treatment. Statistical analysis showed a significant difference (p<0.001). No significant difference .could be detected between the duration of asexual parasitemia of P. falciparum in these two groups (p=0.3085). No statistically significant difference could be detected concerning the duration of fever and the length of hospitalization between these rwo groups.
Co-Authors A. Liando K. Silitonga M. Mogi